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Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS

Spinal cord injury (SCI) often leads to physical limitations, persistent pain, and major lifestyle shifts, enhancing the likelihood of prolonged psychological stress and associated disorders such as anxiety and depression. The mechanisms linking stress with regeneration remain elusive, despite under...

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Autores principales: Ruan, Yu, Cheng, Jin, Dai, Jiafeng, Ma, Zhengwen, Luo, Shiyu, Yan, Run, Wang, Lizhao, Zhou, Jinrui, Yu, Bin, Tong, Xiaoping, Shen, Hongxing, Zhou, Libing, Yuan, Ti-Fei, Han, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558127/
https://www.ncbi.nlm.nih.gov/pubmed/37801508
http://dx.doi.org/10.1126/sciadv.adh0183
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author Ruan, Yu
Cheng, Jin
Dai, Jiafeng
Ma, Zhengwen
Luo, Shiyu
Yan, Run
Wang, Lizhao
Zhou, Jinrui
Yu, Bin
Tong, Xiaoping
Shen, Hongxing
Zhou, Libing
Yuan, Ti-Fei
Han, Qi
author_facet Ruan, Yu
Cheng, Jin
Dai, Jiafeng
Ma, Zhengwen
Luo, Shiyu
Yan, Run
Wang, Lizhao
Zhou, Jinrui
Yu, Bin
Tong, Xiaoping
Shen, Hongxing
Zhou, Libing
Yuan, Ti-Fei
Han, Qi
author_sort Ruan, Yu
collection PubMed
description Spinal cord injury (SCI) often leads to physical limitations, persistent pain, and major lifestyle shifts, enhancing the likelihood of prolonged psychological stress and associated disorders such as anxiety and depression. The mechanisms linking stress with regeneration remain elusive, despite understanding the detrimental impact of chronic stress on SCI recovery. In this study, we investigated the effect of chronic stress on primary sensory axon regeneration using a preconditioning lesions mouse model. Our data revealed that chronic stress–induced mitochondrial cristae loss and a decrease in oxidative phosphorylation (OXPHOS) within primary sensory neurons, impeding central axon regrowth. Corticosterone, a stress hormone, emerged as a pivotal player in this process, affecting satellite glial cells by reducing Kir4.1 expression. This led to increased neuronal hyperactivity and reactive oxygen species levels, which, in turn, deformed mitochondrial cristae and impaired OXPHOS, crucial for axonal regeneration. Our study underscores the need to manage psychological stress in patients with SCI for effective sensory-motor rehabilitation.
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spelling pubmed-105581272023-10-07 Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS Ruan, Yu Cheng, Jin Dai, Jiafeng Ma, Zhengwen Luo, Shiyu Yan, Run Wang, Lizhao Zhou, Jinrui Yu, Bin Tong, Xiaoping Shen, Hongxing Zhou, Libing Yuan, Ti-Fei Han, Qi Sci Adv Neuroscience Spinal cord injury (SCI) often leads to physical limitations, persistent pain, and major lifestyle shifts, enhancing the likelihood of prolonged psychological stress and associated disorders such as anxiety and depression. The mechanisms linking stress with regeneration remain elusive, despite understanding the detrimental impact of chronic stress on SCI recovery. In this study, we investigated the effect of chronic stress on primary sensory axon regeneration using a preconditioning lesions mouse model. Our data revealed that chronic stress–induced mitochondrial cristae loss and a decrease in oxidative phosphorylation (OXPHOS) within primary sensory neurons, impeding central axon regrowth. Corticosterone, a stress hormone, emerged as a pivotal player in this process, affecting satellite glial cells by reducing Kir4.1 expression. This led to increased neuronal hyperactivity and reactive oxygen species levels, which, in turn, deformed mitochondrial cristae and impaired OXPHOS, crucial for axonal regeneration. Our study underscores the need to manage psychological stress in patients with SCI for effective sensory-motor rehabilitation. American Association for the Advancement of Science 2023-10-06 /pmc/articles/PMC10558127/ /pubmed/37801508 http://dx.doi.org/10.1126/sciadv.adh0183 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Neuroscience
Ruan, Yu
Cheng, Jin
Dai, Jiafeng
Ma, Zhengwen
Luo, Shiyu
Yan, Run
Wang, Lizhao
Zhou, Jinrui
Yu, Bin
Tong, Xiaoping
Shen, Hongxing
Zhou, Libing
Yuan, Ti-Fei
Han, Qi
Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS
title Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS
title_full Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS
title_fullStr Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS
title_full_unstemmed Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS
title_short Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS
title_sort chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and oxphos
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558127/
https://www.ncbi.nlm.nih.gov/pubmed/37801508
http://dx.doi.org/10.1126/sciadv.adh0183
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