AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells

Here, we show that the tumor suppressor phosphatase and tensin homolog deleted from chromosome 10 (PTEN) sensitizes cells to ferroptosis, an iron-dependent form of cell death, by restraining the expression and activity of the cystine/glutamate antiporter system X(c)(−) (xCT). Loss of PTEN activates...

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Detalles Bibliográficos
Autores principales: Cahuzac, Kaitlyn M., Lubin, Abigail, Bosch, Kaitlyn, Stokes, Nicole, Shoenfeld, Sarah Mense, Zhou, Royce, Lemon, Haddy, Asara, John, Parsons, Ramon E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558134/
https://www.ncbi.nlm.nih.gov/pubmed/37210723
http://dx.doi.org/10.1016/j.celrep.2023.112536

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