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Structural optimization and prospect of constructing hemoglobin oxygen carriers based on hemoglobin

The current global shortage of organ resources, the imbalance in donor-recipient demand and the increasing number of high-risk donors make organ preservation a necessity to consider appropriate storage options. The current method of use often has risks such as blood group mismatch, short shelf life,...

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Autores principales: Ma, Yuexiang, Zhang, Qi, Dai, Zheng, Li, Jing, Li, Wenxiu, Fu, Chuanqing, Wang, Qianmei, Yin, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558499/
https://www.ncbi.nlm.nih.gov/pubmed/37809714
http://dx.doi.org/10.1016/j.heliyon.2023.e19430
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author Ma, Yuexiang
Zhang, Qi
Dai, Zheng
Li, Jing
Li, Wenxiu
Fu, Chuanqing
Wang, Qianmei
Yin, Wen
author_facet Ma, Yuexiang
Zhang, Qi
Dai, Zheng
Li, Jing
Li, Wenxiu
Fu, Chuanqing
Wang, Qianmei
Yin, Wen
author_sort Ma, Yuexiang
collection PubMed
description The current global shortage of organ resources, the imbalance in donor-recipient demand and the increasing number of high-risk donors make organ preservation a necessity to consider appropriate storage options. The current method of use often has risks such as blood group mismatch, short shelf life, and susceptibility. HBOCs have positive effects such as anti-apoptotic, anti-inflammatory, antioxidant and anti-proliferative, which have significant advantages in organ storage. Therefore, it is the common pursuit of researchers to design and synthesize HBOCs with safety, ideal oxygen-carrying capacity, easy storage, etc. that are widely applicable and optimal for different organs. There has been a recent advancement in understanding HBOCs mechanisms, which is discussed in this review.
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spelling pubmed-105584992023-10-08 Structural optimization and prospect of constructing hemoglobin oxygen carriers based on hemoglobin Ma, Yuexiang Zhang, Qi Dai, Zheng Li, Jing Li, Wenxiu Fu, Chuanqing Wang, Qianmei Yin, Wen Heliyon Review Article The current global shortage of organ resources, the imbalance in donor-recipient demand and the increasing number of high-risk donors make organ preservation a necessity to consider appropriate storage options. The current method of use often has risks such as blood group mismatch, short shelf life, and susceptibility. HBOCs have positive effects such as anti-apoptotic, anti-inflammatory, antioxidant and anti-proliferative, which have significant advantages in organ storage. Therefore, it is the common pursuit of researchers to design and synthesize HBOCs with safety, ideal oxygen-carrying capacity, easy storage, etc. that are widely applicable and optimal for different organs. There has been a recent advancement in understanding HBOCs mechanisms, which is discussed in this review. Elsevier 2023-08-29 /pmc/articles/PMC10558499/ /pubmed/37809714 http://dx.doi.org/10.1016/j.heliyon.2023.e19430 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Ma, Yuexiang
Zhang, Qi
Dai, Zheng
Li, Jing
Li, Wenxiu
Fu, Chuanqing
Wang, Qianmei
Yin, Wen
Structural optimization and prospect of constructing hemoglobin oxygen carriers based on hemoglobin
title Structural optimization and prospect of constructing hemoglobin oxygen carriers based on hemoglobin
title_full Structural optimization and prospect of constructing hemoglobin oxygen carriers based on hemoglobin
title_fullStr Structural optimization and prospect of constructing hemoglobin oxygen carriers based on hemoglobin
title_full_unstemmed Structural optimization and prospect of constructing hemoglobin oxygen carriers based on hemoglobin
title_short Structural optimization and prospect of constructing hemoglobin oxygen carriers based on hemoglobin
title_sort structural optimization and prospect of constructing hemoglobin oxygen carriers based on hemoglobin
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558499/
https://www.ncbi.nlm.nih.gov/pubmed/37809714
http://dx.doi.org/10.1016/j.heliyon.2023.e19430
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