Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq

Genomic and proteomic screens have identified numerous host factors of SARS-CoV-2, but efficient delineation of their molecular roles during infection remains a challenge. Here we use Perturb-seq, combining genetic perturbations with a single-cell readout, to investigate how inactivation of host fac...

Descripción completa

Detalles Bibliográficos
Autores principales: Sunshine, Sara, Puschnik, Andreas S., Replogle, Joseph M., Laurie, Matthew T., Liu, Jamin, Zha, Beth Shoshana, Nuñez, James K., Byrum, Janie R., McMorrow, Aidan H., Frieman, Matthew B., Winkler, Juliane, Qiu, Xiaojie, Rosenberg, Oren S., Leonetti, Manuel D., Ye, Chun Jimmie, Weissman, Jonathan S., DeRisi, Joseph L., Hein, Marco Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558542/
https://www.ncbi.nlm.nih.gov/pubmed/37803001
http://dx.doi.org/10.1038/s41467-023-41788-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558542/
https://www.ncbi.nlm.nih.gov/pubmed/37803001
http://dx.doi.org/10.1038/s41467-023-41788-4

Ejemplares similares