Cargando…
Chronic inflammation does not mediate the effect of adiposity on grip strength: results from a multivariable Mendelian randomization study
The relationship between adiposity and grip strength (GS) is complex. We investigated whether one pathway through which adiposity affects GS was via chronic inflammation. 367,583 UK Biobank participants had body mass index (BMI), waist-hip-ratio (WHR), C-reactive protein (CRP) and GS data. Univariab...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558578/ https://www.ncbi.nlm.nih.gov/pubmed/37803197 http://dx.doi.org/10.1038/s41598-023-43908-y |
_version_ | 1785117308204613632 |
---|---|
author | Norris, Tom Sanderson, Eleanor Cooper, Rachel Garfield, Victoria Pereira, Snehal M. Pinto |
author_facet | Norris, Tom Sanderson, Eleanor Cooper, Rachel Garfield, Victoria Pereira, Snehal M. Pinto |
author_sort | Norris, Tom |
collection | PubMed |
description | The relationship between adiposity and grip strength (GS) is complex. We investigated whether one pathway through which adiposity affects GS was via chronic inflammation. 367,583 UK Biobank participants had body mass index (BMI), waist-hip-ratio (WHR), C-reactive protein (CRP) and GS data. Univariable Mendelian randomization (MR) and multivariable Mendelian randomization (MVMR) analyses (using inverse variance weighted (IVW) weighted median estimates (WME) and MR-Egger models) estimated total, direct and indirect effects of adiposity traits on GS using genetic instruments for BMI and WHR (exposures) and CRP (mediator). Observational findings suggested higher BMI was associated with stronger grip, e.g., in males, per standard deviation (SD) higher BMI, GS was higher by 0.48 kg (95% confidence interval(CI):0.44,0.51), independent of CRP. For males MR estimates were directionally consistent; for females, estimates were consistent with the null. Observational findings for WHR suggested that higher WHR was associated with weaker grip. In multivariable MR-IVW analyses, effects in males were consistent with the null. In females, there were consistent effects such that higher WHR was associated with stronger grip, e.g., 1-SD higher WHR was associated with 1.25 kg (MVMR-Egger; 95% CI:0.72,1.78) stronger grip, independent of CRP. Across sexes and adiposity indicators, CRP’s mediating role was minor. Greater adiposity may increase GS in early old age, but effects vary by sex and adiposity location. There was no evidence that inflammation mediated these effects. |
format | Online Article Text |
id | pubmed-10558578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-105585782023-10-08 Chronic inflammation does not mediate the effect of adiposity on grip strength: results from a multivariable Mendelian randomization study Norris, Tom Sanderson, Eleanor Cooper, Rachel Garfield, Victoria Pereira, Snehal M. Pinto Sci Rep Article The relationship between adiposity and grip strength (GS) is complex. We investigated whether one pathway through which adiposity affects GS was via chronic inflammation. 367,583 UK Biobank participants had body mass index (BMI), waist-hip-ratio (WHR), C-reactive protein (CRP) and GS data. Univariable Mendelian randomization (MR) and multivariable Mendelian randomization (MVMR) analyses (using inverse variance weighted (IVW) weighted median estimates (WME) and MR-Egger models) estimated total, direct and indirect effects of adiposity traits on GS using genetic instruments for BMI and WHR (exposures) and CRP (mediator). Observational findings suggested higher BMI was associated with stronger grip, e.g., in males, per standard deviation (SD) higher BMI, GS was higher by 0.48 kg (95% confidence interval(CI):0.44,0.51), independent of CRP. For males MR estimates were directionally consistent; for females, estimates were consistent with the null. Observational findings for WHR suggested that higher WHR was associated with weaker grip. In multivariable MR-IVW analyses, effects in males were consistent with the null. In females, there were consistent effects such that higher WHR was associated with stronger grip, e.g., 1-SD higher WHR was associated with 1.25 kg (MVMR-Egger; 95% CI:0.72,1.78) stronger grip, independent of CRP. Across sexes and adiposity indicators, CRP’s mediating role was minor. Greater adiposity may increase GS in early old age, but effects vary by sex and adiposity location. There was no evidence that inflammation mediated these effects. Nature Publishing Group UK 2023-10-06 /pmc/articles/PMC10558578/ /pubmed/37803197 http://dx.doi.org/10.1038/s41598-023-43908-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Norris, Tom Sanderson, Eleanor Cooper, Rachel Garfield, Victoria Pereira, Snehal M. Pinto Chronic inflammation does not mediate the effect of adiposity on grip strength: results from a multivariable Mendelian randomization study |
title | Chronic inflammation does not mediate the effect of adiposity on grip strength: results from a multivariable Mendelian randomization study |
title_full | Chronic inflammation does not mediate the effect of adiposity on grip strength: results from a multivariable Mendelian randomization study |
title_fullStr | Chronic inflammation does not mediate the effect of adiposity on grip strength: results from a multivariable Mendelian randomization study |
title_full_unstemmed | Chronic inflammation does not mediate the effect of adiposity on grip strength: results from a multivariable Mendelian randomization study |
title_short | Chronic inflammation does not mediate the effect of adiposity on grip strength: results from a multivariable Mendelian randomization study |
title_sort | chronic inflammation does not mediate the effect of adiposity on grip strength: results from a multivariable mendelian randomization study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558578/ https://www.ncbi.nlm.nih.gov/pubmed/37803197 http://dx.doi.org/10.1038/s41598-023-43908-y |
work_keys_str_mv | AT norristom chronicinflammationdoesnotmediatetheeffectofadiposityongripstrengthresultsfromamultivariablemendelianrandomizationstudy AT sandersoneleanor chronicinflammationdoesnotmediatetheeffectofadiposityongripstrengthresultsfromamultivariablemendelianrandomizationstudy AT cooperrachel chronicinflammationdoesnotmediatetheeffectofadiposityongripstrengthresultsfromamultivariablemendelianrandomizationstudy AT garfieldvictoria chronicinflammationdoesnotmediatetheeffectofadiposityongripstrengthresultsfromamultivariablemendelianrandomizationstudy AT pereirasnehalmpinto chronicinflammationdoesnotmediatetheeffectofadiposityongripstrengthresultsfromamultivariablemendelianrandomizationstudy |