Distinct and targetable role of calcium-sensing receptor in leukaemia

Haematopoietic stem cells (HSC) reside in the bone marrow microenvironment (BMM), where they respond to extracellular calcium [eCa(2+)] via the G-protein coupled calcium-sensing receptor (CaSR). Here we show that a calcium gradient exists in this BMM, and that [eCa(2+)] and response to [eCa(2+)] dif...

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Detalles Bibliográficos
Autores principales: Pereira, Raquel S., Kumar, Rahul, Cais, Alessia, Paulini, Lara, Kahler, Alisa, Bravo, Jimena, Minciacchi, Valentina R., Krack, Theresa, Kowarz, Eric, Zanetti, Costanza, Godavarthy, Parimala Sonika, Hoeller, Fabian, Llavona, Pablo, Stark, Tabea, Tascher, Georg, Nowak, Daniel, Meduri, Eshwar, Huntly, Brian J. P., Münch, Christian, Pampaloni, Francesco, Marschalek, Rolf, Krause, Daniela S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558580/
https://www.ncbi.nlm.nih.gov/pubmed/37802982
http://dx.doi.org/10.1038/s41467-023-41770-0

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