Layer‐Specific BTX‐A Delivery to the Gastric Muscularis Achieves Effective Weight Control and Metabolic Improvement (Adv. Sci. 28/2023)

Precision Gastric Paralysis In article number 2300822, Liang Peng, Jian Zhuang, Hua Meng, and co‐workers report a new system for the precise delivery and distribution of botulinum neurotoxin A (BTX‐A) in the gastric wall to achieve weight loss and metabolic improvement. This work clearly indicates t...

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Detalles Bibliográficos
Autores principales: Wang, Siqi, Wang, Yuqiong, Lin, Long, Li, Zongjie, Liu, Fengyi, Zhu, Long, Chen, Jie, Zhang, Nianrong, Cao, Xinyu, Ran, Sunman, Liu, Genzheng, Gao, Peng, Sun, Weiliang, Peng, Liang, Zhuang, Jian, Meng, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558679/
http://dx.doi.org/10.1002/advs.202370194
Descripción
Sumario:Precision Gastric Paralysis In article number 2300822, Liang Peng, Jian Zhuang, Hua Meng, and co‐workers report a new system for the precise delivery and distribution of botulinum neurotoxin A (BTX‐A) in the gastric wall to achieve weight loss and metabolic improvement. This work clearly indicates the gastric muscularis as the most favorable working site of BTX‐A for weight control, accompanied by improvement in blood glucose, liver steatosis, and gut micro boots. Meanwhile, this work suggests that the layer‐specific gastric paralysis microneedles could serve as a novel clinical approach to effectively produce a positive treatment outcome. [Image: see text]

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