Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer

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To explore mechanisms of response to combined PD-1/CTLA-4 immune checkpoint blockade (ICB) treatment in individual cell types, we generated scRNA-seq using a mouse model of invasive urothelial carcinoma with three conditions: untreated tumor, treated tumor, and tumor treated after CD4(+) T cell depl...

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Detalles Bibliográficos
Autores principales: Freshour, Sharon L., Chen, Timothy H.-P., Fisk, Bryan, Shen, Haolin, Mosior, Matthew, Skidmore, Zachary L., Fronick, Catrina, Bolzenius, Jennifer K., Griffith, Obi L., Arora, Vivek K., Griffith, Malachi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558731/
https://www.ncbi.nlm.nih.gov/pubmed/37810214
http://dx.doi.org/10.1016/j.isci.2023.107937
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