Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report

Small cell lung cancer (SCLC) is a highly aggressive malignancy with a poor outcome. We present the case of a 57-year-old male patient with extensive-stage (ES-SCLC) treated with chemotherapy and atezolizumab. A complete response was achieved with a long remission of ∼three years. Comprehensive geno...

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Autores principales: Tomic, Kresimir, Karan Krizanac, Dragana, Skenderi, Faruk, Krpina, Kristina, Carapina Bilic, Andrea, Galic, Kristina, Gatalica, Zoran, Vranic, Semir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558768/
https://www.ncbi.nlm.nih.gov/pubmed/37810185
http://dx.doi.org/10.1016/j.rmcr.2023.101920
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author Tomic, Kresimir
Karan Krizanac, Dragana
Skenderi, Faruk
Krpina, Kristina
Carapina Bilic, Andrea
Galic, Kristina
Gatalica, Zoran
Vranic, Semir
author_facet Tomic, Kresimir
Karan Krizanac, Dragana
Skenderi, Faruk
Krpina, Kristina
Carapina Bilic, Andrea
Galic, Kristina
Gatalica, Zoran
Vranic, Semir
author_sort Tomic, Kresimir
collection PubMed
description Small cell lung cancer (SCLC) is a highly aggressive malignancy with a poor outcome. We present the case of a 57-year-old male patient with extensive-stage (ES-SCLC) treated with chemotherapy and atezolizumab. A complete response was achieved with a long remission of ∼three years. Comprehensive genomic profiling (CGP) of the tumor revealed high tumor mutation burden (13 mutations/Mb) and mutations of TP53, RB1 and ERCC4 genes. This case study confirms that a complete response to chemoimmunotherapy may be achieved in the case of ES-SCLC. It further provides the additional value of CGP and predictive testing in the management of ES-SCLC.
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spelling pubmed-105587682023-10-08 Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report Tomic, Kresimir Karan Krizanac, Dragana Skenderi, Faruk Krpina, Kristina Carapina Bilic, Andrea Galic, Kristina Gatalica, Zoran Vranic, Semir Respir Med Case Rep Case Report Small cell lung cancer (SCLC) is a highly aggressive malignancy with a poor outcome. We present the case of a 57-year-old male patient with extensive-stage (ES-SCLC) treated with chemotherapy and atezolizumab. A complete response was achieved with a long remission of ∼three years. Comprehensive genomic profiling (CGP) of the tumor revealed high tumor mutation burden (13 mutations/Mb) and mutations of TP53, RB1 and ERCC4 genes. This case study confirms that a complete response to chemoimmunotherapy may be achieved in the case of ES-SCLC. It further provides the additional value of CGP and predictive testing in the management of ES-SCLC. Elsevier 2023-09-26 /pmc/articles/PMC10558768/ /pubmed/37810185 http://dx.doi.org/10.1016/j.rmcr.2023.101920 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Tomic, Kresimir
Karan Krizanac, Dragana
Skenderi, Faruk
Krpina, Kristina
Carapina Bilic, Andrea
Galic, Kristina
Gatalica, Zoran
Vranic, Semir
Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report
title Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report
title_full Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report
title_fullStr Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report
title_full_unstemmed Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report
title_short Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report
title_sort comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558768/
https://www.ncbi.nlm.nih.gov/pubmed/37810185
http://dx.doi.org/10.1016/j.rmcr.2023.101920
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