Essential role of the amino-terminal region of Drosha for the Microprocessor function

Drosha is a core component of the Microprocessor complex that cleaves primary-microRNAs (pri-miRNAs) to generate precursor-miRNA and regulates the expression of ∼80 ribosomal protein (RP) genes. Despite the fact that mutations in the amino-terminal region of Drosha (Drosha-NTR) are associated with a...

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Detalles Bibliográficos
Autores principales: Prabhakar, Amit, Hu, Song, Tang, Jin, Ghatpande, Prajakta, Lagna, Giorgio, Jiang, Xuan, Hata, Akiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558778/
https://www.ncbi.nlm.nih.gov/pubmed/37810246
http://dx.doi.org/10.1016/j.isci.2023.107971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558778/
https://www.ncbi.nlm.nih.gov/pubmed/37810246
http://dx.doi.org/10.1016/j.isci.2023.107971

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