Photopolymerized keratin-PGLa hydrogels for antibiotic resistance reversal and enhancement of infectious wound healing

Infectious wounds have become serious challenges for both treatment and management in clinical practice, so development of new antibiotics has been considered an increasingly difficult task. Here, we report the design and synthesis of keratin 31 (K31)-peptide glycine-leucine-amide (PGLa) photopolyme...

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Detalles Bibliográficos
Autores principales: Sun, Changfa, Liu, Wenjie, Wang, Lili, Meng, Run, Deng, Jia, Qing, Rui, Wang, Bochu, Hao, Shilei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558788/
https://www.ncbi.nlm.nih.gov/pubmed/37810750
http://dx.doi.org/10.1016/j.mtbio.2023.100807
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author Sun, Changfa
Liu, Wenjie
Wang, Lili
Meng, Run
Deng, Jia
Qing, Rui
Wang, Bochu
Hao, Shilei
author_facet Sun, Changfa
Liu, Wenjie
Wang, Lili
Meng, Run
Deng, Jia
Qing, Rui
Wang, Bochu
Hao, Shilei
author_sort Sun, Changfa
collection PubMed
description Infectious wounds have become serious challenges for both treatment and management in clinical practice, so development of new antibiotics has been considered an increasingly difficult task. Here, we report the design and synthesis of keratin 31 (K31)-peptide glycine-leucine-amide (PGLa) photopolymerized hydrogels to rescue the antibiotic activity of antibiotics for infectious wound healing promotion. K31-PGLa displayed an outstanding synergistic effect with commercial antibiotics against drug-resistant bacteria by down-regulating the synthesis genes of efflux pump. Furthermore, the photopolymerized K31-PGLa/PEGDA hydrogels effectively suppressed drug-resistant bacteria growth and enhanced skin wound closure in murine. This study provided a promising alternative strategy for infectious wound treatment.
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spelling pubmed-105587882023-10-08 Photopolymerized keratin-PGLa hydrogels for antibiotic resistance reversal and enhancement of infectious wound healing Sun, Changfa Liu, Wenjie Wang, Lili Meng, Run Deng, Jia Qing, Rui Wang, Bochu Hao, Shilei Mater Today Bio Full Length Article Infectious wounds have become serious challenges for both treatment and management in clinical practice, so development of new antibiotics has been considered an increasingly difficult task. Here, we report the design and synthesis of keratin 31 (K31)-peptide glycine-leucine-amide (PGLa) photopolymerized hydrogels to rescue the antibiotic activity of antibiotics for infectious wound healing promotion. K31-PGLa displayed an outstanding synergistic effect with commercial antibiotics against drug-resistant bacteria by down-regulating the synthesis genes of efflux pump. Furthermore, the photopolymerized K31-PGLa/PEGDA hydrogels effectively suppressed drug-resistant bacteria growth and enhanced skin wound closure in murine. This study provided a promising alternative strategy for infectious wound treatment. Elsevier 2023-09-23 /pmc/articles/PMC10558788/ /pubmed/37810750 http://dx.doi.org/10.1016/j.mtbio.2023.100807 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Full Length Article
Sun, Changfa
Liu, Wenjie
Wang, Lili
Meng, Run
Deng, Jia
Qing, Rui
Wang, Bochu
Hao, Shilei
Photopolymerized keratin-PGLa hydrogels for antibiotic resistance reversal and enhancement of infectious wound healing
title Photopolymerized keratin-PGLa hydrogels for antibiotic resistance reversal and enhancement of infectious wound healing
title_full Photopolymerized keratin-PGLa hydrogels for antibiotic resistance reversal and enhancement of infectious wound healing
title_fullStr Photopolymerized keratin-PGLa hydrogels for antibiotic resistance reversal and enhancement of infectious wound healing
title_full_unstemmed Photopolymerized keratin-PGLa hydrogels for antibiotic resistance reversal and enhancement of infectious wound healing
title_short Photopolymerized keratin-PGLa hydrogels for antibiotic resistance reversal and enhancement of infectious wound healing
title_sort photopolymerized keratin-pgla hydrogels for antibiotic resistance reversal and enhancement of infectious wound healing
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558788/
https://www.ncbi.nlm.nih.gov/pubmed/37810750
http://dx.doi.org/10.1016/j.mtbio.2023.100807
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