Small molecule screen identifies pyrimethamine as an inhibitor of NRF2-driven esophageal hyperplasia

OBJECTIVE: NRF2 is a master transcription factor that regulates the stress response. NRF2 is frequently mutated and activated in human esophageal squamous cell carcinoma (ESCC), which drives resistance to chemotherapy and radiation therapy. Therefore, a great need exists for NRF2 inhibitors for targ...

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Detalles Bibliográficos
Autores principales: Paiboonrungruang, Chorlada, Xiong, Zhaohui, Lamson, David, Li, Yahui, Bowman, Brittany, Chembo, Julius, Huang, Caizhi, Li, Jianying, Livingston, Eric W., Frank, Jon E., Chen, Vivian, Li, Yong, Weissman, Bernard, Yuan, Hong, Williams, Kevin P., Ben Major, M., Chen, Xiaoxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558795/
https://www.ncbi.nlm.nih.gov/pubmed/37776708
http://dx.doi.org/10.1016/j.redox.2023.102901

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