Cargando…
The First Sign of Recurrent Angioimmunoblastic T-Cell Lymphoma: A Cutaneous Presentation
Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma with a nonspecific clinical presentation. Cutaneous manifestations of AITL are variable and include morbilliform eruptions, urticaria, papulonodules, and erythroderma. We present the case of a 74-year-old male with...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558893/ https://www.ncbi.nlm.nih.gov/pubmed/37809113 http://dx.doi.org/10.7759/cureus.44805 |
_version_ | 1785117383621345280 |
---|---|
author | Charest, Guy McBride, Michael Thomas, Amanda K Manway, Mitch DiCaudo, David J |
author_facet | Charest, Guy McBride, Michael Thomas, Amanda K Manway, Mitch DiCaudo, David J |
author_sort | Charest, Guy |
collection | PubMed |
description | Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma with a nonspecific clinical presentation. Cutaneous manifestations of AITL are variable and include morbilliform eruptions, urticaria, papulonodules, and erythroderma. We present the case of a 74-year-old male with a medical history of AITL presenting with diffuse erythematous macules and papules coalescing into patches and plaques on the trunk and bilateral upper extremities. Histopathology demonstrated a mild perivascular lymphocytic infiltrate in the dermis. By immunohistochemistry, the lymphocytic infiltrate was strongly positive for programmed cell death protein 1 (PD-1) (CD279) as well as cluster of differentiation 3 (CD3), CD5, and (focally) B-cell lymphoma-6 (BCL-6). Many cells within the infiltrate were positive for Epstein-Barr virus (EBV) by in situ hybridization. Additionally, a bone marrow biopsy demonstrated an atypical lymphoid infiltrate with T-cell predominance, many EBV-positive cells, and clonal T-cell receptor (TCR) beta gene rearrangement. Based on these histopathological findings, a diagnosis of recurrent AITL with cutaneous involvement was made. This case is a rare example of skin findings presenting as a first sign of recurrent AITL. |
format | Online Article Text |
id | pubmed-10558893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-105588932023-10-08 The First Sign of Recurrent Angioimmunoblastic T-Cell Lymphoma: A Cutaneous Presentation Charest, Guy McBride, Michael Thomas, Amanda K Manway, Mitch DiCaudo, David J Cureus Dermatology Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma with a nonspecific clinical presentation. Cutaneous manifestations of AITL are variable and include morbilliform eruptions, urticaria, papulonodules, and erythroderma. We present the case of a 74-year-old male with a medical history of AITL presenting with diffuse erythematous macules and papules coalescing into patches and plaques on the trunk and bilateral upper extremities. Histopathology demonstrated a mild perivascular lymphocytic infiltrate in the dermis. By immunohistochemistry, the lymphocytic infiltrate was strongly positive for programmed cell death protein 1 (PD-1) (CD279) as well as cluster of differentiation 3 (CD3), CD5, and (focally) B-cell lymphoma-6 (BCL-6). Many cells within the infiltrate were positive for Epstein-Barr virus (EBV) by in situ hybridization. Additionally, a bone marrow biopsy demonstrated an atypical lymphoid infiltrate with T-cell predominance, many EBV-positive cells, and clonal T-cell receptor (TCR) beta gene rearrangement. Based on these histopathological findings, a diagnosis of recurrent AITL with cutaneous involvement was made. This case is a rare example of skin findings presenting as a first sign of recurrent AITL. Cureus 2023-09-06 /pmc/articles/PMC10558893/ /pubmed/37809113 http://dx.doi.org/10.7759/cureus.44805 Text en Copyright © 2023, Charest et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Dermatology Charest, Guy McBride, Michael Thomas, Amanda K Manway, Mitch DiCaudo, David J The First Sign of Recurrent Angioimmunoblastic T-Cell Lymphoma: A Cutaneous Presentation |
title | The First Sign of Recurrent Angioimmunoblastic T-Cell Lymphoma: A Cutaneous Presentation |
title_full | The First Sign of Recurrent Angioimmunoblastic T-Cell Lymphoma: A Cutaneous Presentation |
title_fullStr | The First Sign of Recurrent Angioimmunoblastic T-Cell Lymphoma: A Cutaneous Presentation |
title_full_unstemmed | The First Sign of Recurrent Angioimmunoblastic T-Cell Lymphoma: A Cutaneous Presentation |
title_short | The First Sign of Recurrent Angioimmunoblastic T-Cell Lymphoma: A Cutaneous Presentation |
title_sort | first sign of recurrent angioimmunoblastic t-cell lymphoma: a cutaneous presentation |
topic | Dermatology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558893/ https://www.ncbi.nlm.nih.gov/pubmed/37809113 http://dx.doi.org/10.7759/cureus.44805 |
work_keys_str_mv | AT charestguy thefirstsignofrecurrentangioimmunoblastictcelllymphomaacutaneouspresentation AT mcbridemichael thefirstsignofrecurrentangioimmunoblastictcelllymphomaacutaneouspresentation AT thomasamandak thefirstsignofrecurrentangioimmunoblastictcelllymphomaacutaneouspresentation AT manwaymitch thefirstsignofrecurrentangioimmunoblastictcelllymphomaacutaneouspresentation AT dicaudodavidj thefirstsignofrecurrentangioimmunoblastictcelllymphomaacutaneouspresentation AT charestguy firstsignofrecurrentangioimmunoblastictcelllymphomaacutaneouspresentation AT mcbridemichael firstsignofrecurrentangioimmunoblastictcelllymphomaacutaneouspresentation AT thomasamandak firstsignofrecurrentangioimmunoblastictcelllymphomaacutaneouspresentation AT manwaymitch firstsignofrecurrentangioimmunoblastictcelllymphomaacutaneouspresentation AT dicaudodavidj firstsignofrecurrentangioimmunoblastictcelllymphomaacutaneouspresentation |