Cargando…
Prognostic value of C-reactive protein-to-albumin ratio in acute pancreatitis: a systematic review and meta-analysis
Background: Acute pancreatitis (AP) is a common disorder and although most of the cases are mild, the mortality risk is high when it comes to severe AP. It is therefore important to determine the severity of AP as early as possible. This review aimed to determine the prognostic value of C-reactive p...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558981/ https://www.ncbi.nlm.nih.gov/pubmed/37811202 http://dx.doi.org/10.12688/f1000research.134938.2 |
_version_ | 1785117404223766528 |
---|---|
author | Mariadi, I Ketut Somayana, Gde Shalim, Christina Permata Sindhughosa, Dwijo Anargha Daniella, Dian Purwanta, Made Lady Adelaida |
author_facet | Mariadi, I Ketut Somayana, Gde Shalim, Christina Permata Sindhughosa, Dwijo Anargha Daniella, Dian Purwanta, Made Lady Adelaida |
author_sort | Mariadi, I Ketut |
collection | PubMed |
description | Background: Acute pancreatitis (AP) is a common disorder and although most of the cases are mild, the mortality risk is high when it comes to severe AP. It is therefore important to determine the severity of AP as early as possible. This review aimed to determine the prognostic value of C-reactive protein-to-albumin ratio (CRP/alb ratio) in patients with AP. Methods: We performed a systematic search on the electronic databases PubMed, Science Direct, and Cochrane Library up to January 2023. Studies reporting CRP/alb ratio on admission and its association with severity or mortality in AP patients were included. We calculated pooled mean difference (MD) and their 95% confidence intervals (CI) using a random-effects model. Quality assessment of the included studies was appraised using a Newcastle–Ottawa scale. Results: A total of six studies comprising 2244 patients were included in this meta-analysis. Severe AP had higher CRP/alb ratio on admission than mild-moderate AP (pooled MD: 3.59; 95% CI: 2.51-4.68; p<0.00001). CRP/alb ratio was also significantly higher on non-survivor AP patients compared to survivor AP patients (pooled MD: 2.12; 95% CI: 0.43-3.8; p < 0.01). Conclusion: High CRP/alb ratio can be used as an early predictor of poor prognosis in patients with AP. |
format | Online Article Text |
id | pubmed-10558981 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-105589812023-10-08 Prognostic value of C-reactive protein-to-albumin ratio in acute pancreatitis: a systematic review and meta-analysis Mariadi, I Ketut Somayana, Gde Shalim, Christina Permata Sindhughosa, Dwijo Anargha Daniella, Dian Purwanta, Made Lady Adelaida F1000Res Systematic Review Background: Acute pancreatitis (AP) is a common disorder and although most of the cases are mild, the mortality risk is high when it comes to severe AP. It is therefore important to determine the severity of AP as early as possible. This review aimed to determine the prognostic value of C-reactive protein-to-albumin ratio (CRP/alb ratio) in patients with AP. Methods: We performed a systematic search on the electronic databases PubMed, Science Direct, and Cochrane Library up to January 2023. Studies reporting CRP/alb ratio on admission and its association with severity or mortality in AP patients were included. We calculated pooled mean difference (MD) and their 95% confidence intervals (CI) using a random-effects model. Quality assessment of the included studies was appraised using a Newcastle–Ottawa scale. Results: A total of six studies comprising 2244 patients were included in this meta-analysis. Severe AP had higher CRP/alb ratio on admission than mild-moderate AP (pooled MD: 3.59; 95% CI: 2.51-4.68; p<0.00001). CRP/alb ratio was also significantly higher on non-survivor AP patients compared to survivor AP patients (pooled MD: 2.12; 95% CI: 0.43-3.8; p < 0.01). Conclusion: High CRP/alb ratio can be used as an early predictor of poor prognosis in patients with AP. F1000 Research Limited 2023-09-22 /pmc/articles/PMC10558981/ /pubmed/37811202 http://dx.doi.org/10.12688/f1000research.134938.2 Text en Copyright: © 2023 Mariadi IK et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Systematic Review Mariadi, I Ketut Somayana, Gde Shalim, Christina Permata Sindhughosa, Dwijo Anargha Daniella, Dian Purwanta, Made Lady Adelaida Prognostic value of C-reactive protein-to-albumin ratio in acute pancreatitis: a systematic review and meta-analysis |
title | Prognostic value of C-reactive protein-to-albumin ratio in acute pancreatitis: a systematic review and meta-analysis |
title_full | Prognostic value of C-reactive protein-to-albumin ratio in acute pancreatitis: a systematic review and meta-analysis |
title_fullStr | Prognostic value of C-reactive protein-to-albumin ratio in acute pancreatitis: a systematic review and meta-analysis |
title_full_unstemmed | Prognostic value of C-reactive protein-to-albumin ratio in acute pancreatitis: a systematic review and meta-analysis |
title_short | Prognostic value of C-reactive protein-to-albumin ratio in acute pancreatitis: a systematic review and meta-analysis |
title_sort | prognostic value of c-reactive protein-to-albumin ratio in acute pancreatitis: a systematic review and meta-analysis |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10558981/ https://www.ncbi.nlm.nih.gov/pubmed/37811202 http://dx.doi.org/10.12688/f1000research.134938.2 |
work_keys_str_mv | AT mariadiiketut prognosticvalueofcreactiveproteintoalbuminratioinacutepancreatitisasystematicreviewandmetaanalysis AT somayanagde prognosticvalueofcreactiveproteintoalbuminratioinacutepancreatitisasystematicreviewandmetaanalysis AT shalimchristinapermata prognosticvalueofcreactiveproteintoalbuminratioinacutepancreatitisasystematicreviewandmetaanalysis AT sindhughosadwijoanargha prognosticvalueofcreactiveproteintoalbuminratioinacutepancreatitisasystematicreviewandmetaanalysis AT danielladian prognosticvalueofcreactiveproteintoalbuminratioinacutepancreatitisasystematicreviewandmetaanalysis AT purwantamadeladyadelaida prognosticvalueofcreactiveproteintoalbuminratioinacutepancreatitisasystematicreviewandmetaanalysis |