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Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle
Here, we present a case with genetically confirmed SCN. The main symptom of the child was recurring fever. The combination of antibiotics combined with G-CSF injection was proved to be insufficient, and the patient developed "solid" liver abscess. After undergoing surgical anatomical hepat...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559282/ https://www.ncbi.nlm.nih.gov/pubmed/37810153 http://dx.doi.org/10.1016/j.heliyon.2023.e19880 |
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author | Lao, Jing Song, Xin-Ping Wang, Huan-Sheng Jiang, Ren-Sen Luo, Yu Sun, Jun Li, Zhi-Han Li, Chi Deng, Ji-Kui Wang, Bin Ma, Xiao-Peng Wang, Jian-Yao |
author_facet | Lao, Jing Song, Xin-Ping Wang, Huan-Sheng Jiang, Ren-Sen Luo, Yu Sun, Jun Li, Zhi-Han Li, Chi Deng, Ji-Kui Wang, Bin Ma, Xiao-Peng Wang, Jian-Yao |
author_sort | Lao, Jing |
collection | PubMed |
description | Here, we present a case with genetically confirmed SCN. The main symptom of the child was recurring fever. The combination of antibiotics combined with G-CSF injection was proved to be insufficient, and the patient developed "solid" liver abscess. After undergoing surgical anatomical hepatic lobectomy, the child's infection symptoms showed improvement. The postoperative culture of the purulent material from the liver infection lesion revealed an infection with Staphylococcus aureus. Our case raises the possibility of pathogen sources and routes of infection, clinical characteristics, and effective treatment for SCN patients with concomitant liver abscess. |
format | Online Article Text |
id | pubmed-10559282 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-105592822023-10-08 Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle Lao, Jing Song, Xin-Ping Wang, Huan-Sheng Jiang, Ren-Sen Luo, Yu Sun, Jun Li, Zhi-Han Li, Chi Deng, Ji-Kui Wang, Bin Ma, Xiao-Peng Wang, Jian-Yao Heliyon Case Report Here, we present a case with genetically confirmed SCN. The main symptom of the child was recurring fever. The combination of antibiotics combined with G-CSF injection was proved to be insufficient, and the patient developed "solid" liver abscess. After undergoing surgical anatomical hepatic lobectomy, the child's infection symptoms showed improvement. The postoperative culture of the purulent material from the liver infection lesion revealed an infection with Staphylococcus aureus. Our case raises the possibility of pathogen sources and routes of infection, clinical characteristics, and effective treatment for SCN patients with concomitant liver abscess. Elsevier 2023-09-12 /pmc/articles/PMC10559282/ /pubmed/37810153 http://dx.doi.org/10.1016/j.heliyon.2023.e19880 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Lao, Jing Song, Xin-Ping Wang, Huan-Sheng Jiang, Ren-Sen Luo, Yu Sun, Jun Li, Zhi-Han Li, Chi Deng, Ji-Kui Wang, Bin Ma, Xiao-Peng Wang, Jian-Yao Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle |
title | Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle |
title_full | Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle |
title_fullStr | Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle |
title_full_unstemmed | Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle |
title_short | Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle |
title_sort | severe congenital neutropenia and liver abscess: surgical treatment breaks the vicious cycle |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559282/ https://www.ncbi.nlm.nih.gov/pubmed/37810153 http://dx.doi.org/10.1016/j.heliyon.2023.e19880 |
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