Cargando…

Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle

Here, we present a case with genetically confirmed SCN. The main symptom of the child was recurring fever. The combination of antibiotics combined with G-CSF injection was proved to be insufficient, and the patient developed "solid" liver abscess. After undergoing surgical anatomical hepat...

Descripción completa

Detalles Bibliográficos
Autores principales: Lao, Jing, Song, Xin-Ping, Wang, Huan-Sheng, Jiang, Ren-Sen, Luo, Yu, Sun, Jun, Li, Zhi-Han, Li, Chi, Deng, Ji-Kui, Wang, Bin, Ma, Xiao-Peng, Wang, Jian-Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559282/
https://www.ncbi.nlm.nih.gov/pubmed/37810153
http://dx.doi.org/10.1016/j.heliyon.2023.e19880
_version_ 1785117464675221504
author Lao, Jing
Song, Xin-Ping
Wang, Huan-Sheng
Jiang, Ren-Sen
Luo, Yu
Sun, Jun
Li, Zhi-Han
Li, Chi
Deng, Ji-Kui
Wang, Bin
Ma, Xiao-Peng
Wang, Jian-Yao
author_facet Lao, Jing
Song, Xin-Ping
Wang, Huan-Sheng
Jiang, Ren-Sen
Luo, Yu
Sun, Jun
Li, Zhi-Han
Li, Chi
Deng, Ji-Kui
Wang, Bin
Ma, Xiao-Peng
Wang, Jian-Yao
author_sort Lao, Jing
collection PubMed
description Here, we present a case with genetically confirmed SCN. The main symptom of the child was recurring fever. The combination of antibiotics combined with G-CSF injection was proved to be insufficient, and the patient developed "solid" liver abscess. After undergoing surgical anatomical hepatic lobectomy, the child's infection symptoms showed improvement. The postoperative culture of the purulent material from the liver infection lesion revealed an infection with Staphylococcus aureus. Our case raises the possibility of pathogen sources and routes of infection, clinical characteristics, and effective treatment for SCN patients with concomitant liver abscess.
format Online
Article
Text
id pubmed-10559282
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-105592822023-10-08 Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle Lao, Jing Song, Xin-Ping Wang, Huan-Sheng Jiang, Ren-Sen Luo, Yu Sun, Jun Li, Zhi-Han Li, Chi Deng, Ji-Kui Wang, Bin Ma, Xiao-Peng Wang, Jian-Yao Heliyon Case Report Here, we present a case with genetically confirmed SCN. The main symptom of the child was recurring fever. The combination of antibiotics combined with G-CSF injection was proved to be insufficient, and the patient developed "solid" liver abscess. After undergoing surgical anatomical hepatic lobectomy, the child's infection symptoms showed improvement. The postoperative culture of the purulent material from the liver infection lesion revealed an infection with Staphylococcus aureus. Our case raises the possibility of pathogen sources and routes of infection, clinical characteristics, and effective treatment for SCN patients with concomitant liver abscess. Elsevier 2023-09-12 /pmc/articles/PMC10559282/ /pubmed/37810153 http://dx.doi.org/10.1016/j.heliyon.2023.e19880 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Lao, Jing
Song, Xin-Ping
Wang, Huan-Sheng
Jiang, Ren-Sen
Luo, Yu
Sun, Jun
Li, Zhi-Han
Li, Chi
Deng, Ji-Kui
Wang, Bin
Ma, Xiao-Peng
Wang, Jian-Yao
Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle
title Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle
title_full Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle
title_fullStr Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle
title_full_unstemmed Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle
title_short Severe congenital neutropenia and liver abscess: Surgical treatment breaks the vicious cycle
title_sort severe congenital neutropenia and liver abscess: surgical treatment breaks the vicious cycle
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559282/
https://www.ncbi.nlm.nih.gov/pubmed/37810153
http://dx.doi.org/10.1016/j.heliyon.2023.e19880
work_keys_str_mv AT laojing severecongenitalneutropeniaandliverabscesssurgicaltreatmentbreakstheviciouscycle
AT songxinping severecongenitalneutropeniaandliverabscesssurgicaltreatmentbreakstheviciouscycle
AT wanghuansheng severecongenitalneutropeniaandliverabscesssurgicaltreatmentbreakstheviciouscycle
AT jiangrensen severecongenitalneutropeniaandliverabscesssurgicaltreatmentbreakstheviciouscycle
AT luoyu severecongenitalneutropeniaandliverabscesssurgicaltreatmentbreakstheviciouscycle
AT sunjun severecongenitalneutropeniaandliverabscesssurgicaltreatmentbreakstheviciouscycle
AT lizhihan severecongenitalneutropeniaandliverabscesssurgicaltreatmentbreakstheviciouscycle
AT lichi severecongenitalneutropeniaandliverabscesssurgicaltreatmentbreakstheviciouscycle
AT dengjikui severecongenitalneutropeniaandliverabscesssurgicaltreatmentbreakstheviciouscycle
AT wangbin severecongenitalneutropeniaandliverabscesssurgicaltreatmentbreakstheviciouscycle
AT maxiaopeng severecongenitalneutropeniaandliverabscesssurgicaltreatmentbreakstheviciouscycle
AT wangjianyao severecongenitalneutropeniaandliverabscesssurgicaltreatmentbreakstheviciouscycle