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Genetically predicted obstructive sleep apnea is causally associated with an increased risk for periodontitis
BACKGROUND: Although obstructive sleep apnea (OSA) and periodontitis are associated, whether this association is causative is uncertain. METHODS: We conducted a bidirectional Mendelian randomization (MR) analysis using data from publically accessible genome-wide association studies. The single-nucle...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559524/ https://www.ncbi.nlm.nih.gov/pubmed/37803323 http://dx.doi.org/10.1186/s12903-023-03338-8 |
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author | Mi, Zhongqian Meng, Nan Zhang, Yitao Wang, Qianqian Song, Shan Cheng, Rui Xu, Xiaojiang Gao, Jinhua Yu, Feiyan Ren, Xiuyun |
author_facet | Mi, Zhongqian Meng, Nan Zhang, Yitao Wang, Qianqian Song, Shan Cheng, Rui Xu, Xiaojiang Gao, Jinhua Yu, Feiyan Ren, Xiuyun |
author_sort | Mi, Zhongqian |
collection | PubMed |
description | BACKGROUND: Although obstructive sleep apnea (OSA) and periodontitis are associated, whether this association is causative is uncertain. METHODS: We conducted a bidirectional Mendelian randomization (MR) analysis using data from publically accessible genome-wide association studies. The single-nucleotide polymorphisms (SNPs) for OSA were derived from 16,761 cases and 201,194 controls. The pooled data of periodontitis association involved up to 17,353 individuals. Disease-associated single-nucleotide polymorphisms were selected as an instrumental variable at the genome-wide significance level (p < 5.0 × 10(− 6)). Subsequently, the causal effects were estimated using three different methods: inverse variance weighting (IVW), MR-Egger, and weighted median. Then, these causal estimates were expressed as dominance ratios [odds ratio (OR)]. RESULTS: The MR analysis revealed that genetically determined OSA promotes the development of periodontitis [ IVW OR = 1.117, 95% confidence interval (CI) = 1.001–1.246, p = 0.048). Furthermore, no causal effect of genetically predicted periodontitis on OSA was noted in the reverse MR analysis (IVW OR = 1, 95% CI: 0.95–1.06, p = 0.87). The trend in results from the MR-Egger regression and weighted median (WM) was consistent with that in results from the IVW method. The robustness of the results was confirmed by the sensitivity analysis. CONCLUSIONS: In summary, the results of our MR investigation suggest an association between OSA and periodontitis, proposing that early screening and treatment of OSA is beneficial for the prevention and prognosis of periodontitis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12903-023-03338-8. |
format | Online Article Text |
id | pubmed-10559524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105595242023-10-08 Genetically predicted obstructive sleep apnea is causally associated with an increased risk for periodontitis Mi, Zhongqian Meng, Nan Zhang, Yitao Wang, Qianqian Song, Shan Cheng, Rui Xu, Xiaojiang Gao, Jinhua Yu, Feiyan Ren, Xiuyun BMC Oral Health Research BACKGROUND: Although obstructive sleep apnea (OSA) and periodontitis are associated, whether this association is causative is uncertain. METHODS: We conducted a bidirectional Mendelian randomization (MR) analysis using data from publically accessible genome-wide association studies. The single-nucleotide polymorphisms (SNPs) for OSA were derived from 16,761 cases and 201,194 controls. The pooled data of periodontitis association involved up to 17,353 individuals. Disease-associated single-nucleotide polymorphisms were selected as an instrumental variable at the genome-wide significance level (p < 5.0 × 10(− 6)). Subsequently, the causal effects were estimated using three different methods: inverse variance weighting (IVW), MR-Egger, and weighted median. Then, these causal estimates were expressed as dominance ratios [odds ratio (OR)]. RESULTS: The MR analysis revealed that genetically determined OSA promotes the development of periodontitis [ IVW OR = 1.117, 95% confidence interval (CI) = 1.001–1.246, p = 0.048). Furthermore, no causal effect of genetically predicted periodontitis on OSA was noted in the reverse MR analysis (IVW OR = 1, 95% CI: 0.95–1.06, p = 0.87). The trend in results from the MR-Egger regression and weighted median (WM) was consistent with that in results from the IVW method. The robustness of the results was confirmed by the sensitivity analysis. CONCLUSIONS: In summary, the results of our MR investigation suggest an association between OSA and periodontitis, proposing that early screening and treatment of OSA is beneficial for the prevention and prognosis of periodontitis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12903-023-03338-8. BioMed Central 2023-10-06 /pmc/articles/PMC10559524/ /pubmed/37803323 http://dx.doi.org/10.1186/s12903-023-03338-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Mi, Zhongqian Meng, Nan Zhang, Yitao Wang, Qianqian Song, Shan Cheng, Rui Xu, Xiaojiang Gao, Jinhua Yu, Feiyan Ren, Xiuyun Genetically predicted obstructive sleep apnea is causally associated with an increased risk for periodontitis |
title | Genetically predicted obstructive sleep apnea is causally associated with an increased risk for periodontitis |
title_full | Genetically predicted obstructive sleep apnea is causally associated with an increased risk for periodontitis |
title_fullStr | Genetically predicted obstructive sleep apnea is causally associated with an increased risk for periodontitis |
title_full_unstemmed | Genetically predicted obstructive sleep apnea is causally associated with an increased risk for periodontitis |
title_short | Genetically predicted obstructive sleep apnea is causally associated with an increased risk for periodontitis |
title_sort | genetically predicted obstructive sleep apnea is causally associated with an increased risk for periodontitis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559524/ https://www.ncbi.nlm.nih.gov/pubmed/37803323 http://dx.doi.org/10.1186/s12903-023-03338-8 |
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