CRISPR/Cas9-mediated knockout of intracellular molecule SHP-1 enhances tumor-killing ability of CD133-targeted CAR T cells in vitro

CAR T cell therapy has been successfully used in the treatment of hematological malignancies, and the strategy that deletion of inhibitory receptor on the CAR T cell surface, such as PD-1, greatly enhance the antitumor effects. Here, we describe a one-step electroporation for the co-transfection of...

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Detalles Bibliográficos
Autores principales: Liu, Ming, Zhang, Linlin, Zhong, Mingtian, Long, Yihao, Yang, Wenhui, Liu, Ting, Huang, Xingxu, Ma, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559533/
https://www.ncbi.nlm.nih.gov/pubmed/37803455
http://dx.doi.org/10.1186/s40164-023-00450-x

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