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Association between lean body mass to visceral fat mass ratio and bone mineral density in United States population: a cross-sectional study

BACKGROUND: Studies have explored the correlation between body composition and bone mineral density (BMD), but there has yet to be a consensus. Thus, the present study aims to comprehensively investigate the association between lean body mass, adipose tissue, and BMD. METHODS: We conducted a cross-s...

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Autores principales: Li, Longti, Zhong, Huiqin, Shao, Ya, Zhou, Xu, Hua, Yu, Chen, Maoqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559600/
https://www.ncbi.nlm.nih.gov/pubmed/37803458
http://dx.doi.org/10.1186/s13690-023-01190-4
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author Li, Longti
Zhong, Huiqin
Shao, Ya
Zhou, Xu
Hua, Yu
Chen, Maoqian
author_facet Li, Longti
Zhong, Huiqin
Shao, Ya
Zhou, Xu
Hua, Yu
Chen, Maoqian
author_sort Li, Longti
collection PubMed
description BACKGROUND: Studies have explored the correlation between body composition and bone mineral density (BMD), but there has yet to be a consensus. Thus, the present study aims to comprehensively investigate the association between lean body mass, adipose tissue, and BMD. METHODS: We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) (2011–2018) with 11,227 subjects. Multiple linear regression, smoothed curve fitting, threshold, and saturation effect analysis were used to explore the association between lean body mass, visceral fat mass, and BMD. Also, we used the lean body mass to visceral fat mass ratio (Log LM/VFM) as a proxy variable to analyze its association with BMD alone. RESULTS: After adjusting for potential confounding factors, the results showed a positive correlation between lean mass and total BMD (for continuous: β = 0.078, P < 0.001; for quartile: β = 0.138, P < 0.001), while visceral fat mass was negatively correlated (for continuous: β = -0.027, P < 0.001; for quartile: β = -0.065, P < 0.001). A positive correlation was observed when the alternative variable Log LM/VFM was analyzed separately for its association with BMD (for continuous: β = 0.034, P < 0.001; for quartile: β = 0.084, P < 0.001). In addition, subgroup analyses for gender, age, body mass index, hypertension, and diabetes showed that all subgroups except the diabetes subgroup showed a substantial degree of robustness (P < 0.05). The smoothed curve fitting showed a nonlinear relationship between Log LM/VFM and BMD, and there was a threshold effect with a critical value of 2.60. CONCLUSION: Maintaining a proper ratio of lean body mass and visceral fat mass is beneficial for increasing BMD.
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spelling pubmed-105596002023-10-08 Association between lean body mass to visceral fat mass ratio and bone mineral density in United States population: a cross-sectional study Li, Longti Zhong, Huiqin Shao, Ya Zhou, Xu Hua, Yu Chen, Maoqian Arch Public Health Research BACKGROUND: Studies have explored the correlation between body composition and bone mineral density (BMD), but there has yet to be a consensus. Thus, the present study aims to comprehensively investigate the association between lean body mass, adipose tissue, and BMD. METHODS: We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) (2011–2018) with 11,227 subjects. Multiple linear regression, smoothed curve fitting, threshold, and saturation effect analysis were used to explore the association between lean body mass, visceral fat mass, and BMD. Also, we used the lean body mass to visceral fat mass ratio (Log LM/VFM) as a proxy variable to analyze its association with BMD alone. RESULTS: After adjusting for potential confounding factors, the results showed a positive correlation between lean mass and total BMD (for continuous: β = 0.078, P < 0.001; for quartile: β = 0.138, P < 0.001), while visceral fat mass was negatively correlated (for continuous: β = -0.027, P < 0.001; for quartile: β = -0.065, P < 0.001). A positive correlation was observed when the alternative variable Log LM/VFM was analyzed separately for its association with BMD (for continuous: β = 0.034, P < 0.001; for quartile: β = 0.084, P < 0.001). In addition, subgroup analyses for gender, age, body mass index, hypertension, and diabetes showed that all subgroups except the diabetes subgroup showed a substantial degree of robustness (P < 0.05). The smoothed curve fitting showed a nonlinear relationship between Log LM/VFM and BMD, and there was a threshold effect with a critical value of 2.60. CONCLUSION: Maintaining a proper ratio of lean body mass and visceral fat mass is beneficial for increasing BMD. BioMed Central 2023-10-06 /pmc/articles/PMC10559600/ /pubmed/37803458 http://dx.doi.org/10.1186/s13690-023-01190-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Li, Longti
Zhong, Huiqin
Shao, Ya
Zhou, Xu
Hua, Yu
Chen, Maoqian
Association between lean body mass to visceral fat mass ratio and bone mineral density in United States population: a cross-sectional study
title Association between lean body mass to visceral fat mass ratio and bone mineral density in United States population: a cross-sectional study
title_full Association between lean body mass to visceral fat mass ratio and bone mineral density in United States population: a cross-sectional study
title_fullStr Association between lean body mass to visceral fat mass ratio and bone mineral density in United States population: a cross-sectional study
title_full_unstemmed Association between lean body mass to visceral fat mass ratio and bone mineral density in United States population: a cross-sectional study
title_short Association between lean body mass to visceral fat mass ratio and bone mineral density in United States population: a cross-sectional study
title_sort association between lean body mass to visceral fat mass ratio and bone mineral density in united states population: a cross-sectional study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559600/
https://www.ncbi.nlm.nih.gov/pubmed/37803458
http://dx.doi.org/10.1186/s13690-023-01190-4
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