Cargando…
Response to a low-energy meal replacement plan on glycometabolic profile and reverse cardiac remodelling in type 2 diabetes: a comparison between South Asians and White Europeans
BACKGROUND: South Asians (SA) constitute a quarter of the global population and are disproportionally affected by both type 2 diabetes (T2D) and heart failure. There remains limited data of the acceptability and efficacy of low-energy meal replacement plans to induce remission of T2D in SA. OBJECTIV...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559709/ https://www.ncbi.nlm.nih.gov/pubmed/37811525 http://dx.doi.org/10.1177/20420188231193231 |
_version_ | 1785117563768799232 |
---|---|
author | Athithan, Lavanya Gulsin, Gaurav S. Henson, Joseph Althagafi, Loai Redman, Emma Argyridou, Stavroula Parke, Kelly S. Yeo, Jian Yates, Thomas Khunti, Kamlesh Davies, Melanie J. McCann, Gerry P. Brady, Emer M. |
author_facet | Athithan, Lavanya Gulsin, Gaurav S. Henson, Joseph Althagafi, Loai Redman, Emma Argyridou, Stavroula Parke, Kelly S. Yeo, Jian Yates, Thomas Khunti, Kamlesh Davies, Melanie J. McCann, Gerry P. Brady, Emer M. |
author_sort | Athithan, Lavanya |
collection | PubMed |
description | BACKGROUND: South Asians (SA) constitute a quarter of the global population and are disproportionally affected by both type 2 diabetes (T2D) and heart failure. There remains limited data of the acceptability and efficacy of low-energy meal replacement plans to induce remission of T2D in SA. OBJECTIVES: The objective of this exploratory secondary analysis of the DIASTOLIC study was to determine if there was a differential uptake, glycometabolic and cardiovascular response to a low-energy meal replacement plan (MRP) between SA and White European (WE) people with T2D. METHODS: Obese adults with T2D without symptomatic cardiovascular disease were allocated a low-energy (~810 kcal/day) MRP as part of the DIASTOLIC study (NCT02590822). Comprehensive multiparametric cardiovascular magnetic resonance imaging, echocardiography, cardiopulmonary exercise testing and metabolic profiling were undertaken at baseline and 12 weeks. A comparison of change at 12 weeks between groups with baseline adjustment was undertaken. RESULTS: Fifteen WE and 12 SAs were allocated the MRP. All WE participants completed the MRP versus 8/12 (66%) SAs. The degree of concentric left ventricular remodelling was similar between ethnicities. Despite similar weight loss and reduction in liver fat percentage, SA had a lower reduction in Homeostatic Model Assessment for Insulin Resistance [−5.7 (95% CI: −7.3, −4.2) versus −8.6 (−9.7, −7.6), p = 0.005] and visceral adiposity compared to WE [−0.43% (−0.61, −0.25) versus −0.80% (−0.91, −0.68), p = 0.002]. Exercise capacity increased in WE with no change observed in SA. There was a trend towards more reverse remodelling in WE compared to SAs. CONCLUSIONS: Compliance to the MRP was lower in SA versus WE. Overall, those completing the MRP saw improvements in weight, body composition and indices of glycaemic control irrespective of ethnicity. Whilst improvements in VAT and insulin resistance appear to be dampened in SA versus WE, given the small sample, larger studies are required to confirm or challenge this potential ethnic disparity. TRAIL REGISTRATION: NCT02590822. |
format | Online Article Text |
id | pubmed-10559709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-105597092023-10-08 Response to a low-energy meal replacement plan on glycometabolic profile and reverse cardiac remodelling in type 2 diabetes: a comparison between South Asians and White Europeans Athithan, Lavanya Gulsin, Gaurav S. Henson, Joseph Althagafi, Loai Redman, Emma Argyridou, Stavroula Parke, Kelly S. Yeo, Jian Yates, Thomas Khunti, Kamlesh Davies, Melanie J. McCann, Gerry P. Brady, Emer M. Ther Adv Endocrinol Metab Original Research BACKGROUND: South Asians (SA) constitute a quarter of the global population and are disproportionally affected by both type 2 diabetes (T2D) and heart failure. There remains limited data of the acceptability and efficacy of low-energy meal replacement plans to induce remission of T2D in SA. OBJECTIVES: The objective of this exploratory secondary analysis of the DIASTOLIC study was to determine if there was a differential uptake, glycometabolic and cardiovascular response to a low-energy meal replacement plan (MRP) between SA and White European (WE) people with T2D. METHODS: Obese adults with T2D without symptomatic cardiovascular disease were allocated a low-energy (~810 kcal/day) MRP as part of the DIASTOLIC study (NCT02590822). Comprehensive multiparametric cardiovascular magnetic resonance imaging, echocardiography, cardiopulmonary exercise testing and metabolic profiling were undertaken at baseline and 12 weeks. A comparison of change at 12 weeks between groups with baseline adjustment was undertaken. RESULTS: Fifteen WE and 12 SAs were allocated the MRP. All WE participants completed the MRP versus 8/12 (66%) SAs. The degree of concentric left ventricular remodelling was similar between ethnicities. Despite similar weight loss and reduction in liver fat percentage, SA had a lower reduction in Homeostatic Model Assessment for Insulin Resistance [−5.7 (95% CI: −7.3, −4.2) versus −8.6 (−9.7, −7.6), p = 0.005] and visceral adiposity compared to WE [−0.43% (−0.61, −0.25) versus −0.80% (−0.91, −0.68), p = 0.002]. Exercise capacity increased in WE with no change observed in SA. There was a trend towards more reverse remodelling in WE compared to SAs. CONCLUSIONS: Compliance to the MRP was lower in SA versus WE. Overall, those completing the MRP saw improvements in weight, body composition and indices of glycaemic control irrespective of ethnicity. Whilst improvements in VAT and insulin resistance appear to be dampened in SA versus WE, given the small sample, larger studies are required to confirm or challenge this potential ethnic disparity. TRAIL REGISTRATION: NCT02590822. SAGE Publications 2023-10-06 /pmc/articles/PMC10559709/ /pubmed/37811525 http://dx.doi.org/10.1177/20420188231193231 Text en © The Author(s), 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Athithan, Lavanya Gulsin, Gaurav S. Henson, Joseph Althagafi, Loai Redman, Emma Argyridou, Stavroula Parke, Kelly S. Yeo, Jian Yates, Thomas Khunti, Kamlesh Davies, Melanie J. McCann, Gerry P. Brady, Emer M. Response to a low-energy meal replacement plan on glycometabolic profile and reverse cardiac remodelling in type 2 diabetes: a comparison between South Asians and White Europeans |
title | Response to a low-energy meal replacement plan on glycometabolic profile and reverse cardiac remodelling in type 2 diabetes: a comparison between South Asians and White Europeans |
title_full | Response to a low-energy meal replacement plan on glycometabolic profile and reverse cardiac remodelling in type 2 diabetes: a comparison between South Asians and White Europeans |
title_fullStr | Response to a low-energy meal replacement plan on glycometabolic profile and reverse cardiac remodelling in type 2 diabetes: a comparison between South Asians and White Europeans |
title_full_unstemmed | Response to a low-energy meal replacement plan on glycometabolic profile and reverse cardiac remodelling in type 2 diabetes: a comparison between South Asians and White Europeans |
title_short | Response to a low-energy meal replacement plan on glycometabolic profile and reverse cardiac remodelling in type 2 diabetes: a comparison between South Asians and White Europeans |
title_sort | response to a low-energy meal replacement plan on glycometabolic profile and reverse cardiac remodelling in type 2 diabetes: a comparison between south asians and white europeans |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559709/ https://www.ncbi.nlm.nih.gov/pubmed/37811525 http://dx.doi.org/10.1177/20420188231193231 |
work_keys_str_mv | AT athithanlavanya responsetoalowenergymealreplacementplanonglycometabolicprofileandreversecardiacremodellingintype2diabetesacomparisonbetweensouthasiansandwhiteeuropeans AT gulsingauravs responsetoalowenergymealreplacementplanonglycometabolicprofileandreversecardiacremodellingintype2diabetesacomparisonbetweensouthasiansandwhiteeuropeans AT hensonjoseph responsetoalowenergymealreplacementplanonglycometabolicprofileandreversecardiacremodellingintype2diabetesacomparisonbetweensouthasiansandwhiteeuropeans AT althagafiloai responsetoalowenergymealreplacementplanonglycometabolicprofileandreversecardiacremodellingintype2diabetesacomparisonbetweensouthasiansandwhiteeuropeans AT redmanemma responsetoalowenergymealreplacementplanonglycometabolicprofileandreversecardiacremodellingintype2diabetesacomparisonbetweensouthasiansandwhiteeuropeans AT argyridoustavroula responsetoalowenergymealreplacementplanonglycometabolicprofileandreversecardiacremodellingintype2diabetesacomparisonbetweensouthasiansandwhiteeuropeans AT parkekellys responsetoalowenergymealreplacementplanonglycometabolicprofileandreversecardiacremodellingintype2diabetesacomparisonbetweensouthasiansandwhiteeuropeans AT yeojian responsetoalowenergymealreplacementplanonglycometabolicprofileandreversecardiacremodellingintype2diabetesacomparisonbetweensouthasiansandwhiteeuropeans AT yatesthomas responsetoalowenergymealreplacementplanonglycometabolicprofileandreversecardiacremodellingintype2diabetesacomparisonbetweensouthasiansandwhiteeuropeans AT khuntikamlesh responsetoalowenergymealreplacementplanonglycometabolicprofileandreversecardiacremodellingintype2diabetesacomparisonbetweensouthasiansandwhiteeuropeans AT daviesmelaniej responsetoalowenergymealreplacementplanonglycometabolicprofileandreversecardiacremodellingintype2diabetesacomparisonbetweensouthasiansandwhiteeuropeans AT mccanngerryp responsetoalowenergymealreplacementplanonglycometabolicprofileandreversecardiacremodellingintype2diabetesacomparisonbetweensouthasiansandwhiteeuropeans AT bradyemerm responsetoalowenergymealreplacementplanonglycometabolicprofileandreversecardiacremodellingintype2diabetesacomparisonbetweensouthasiansandwhiteeuropeans |