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Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess

BACKGROUND: Low muscle mass/sarcopenia has been associated with poor prognosis in many diseases, but its clinical significance in pyogenic liver abscess (PLA) remains unclear. The purpose of this study is to investigate the relationship between muscle mass and prognosis of patients with PLA. METHODS...

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Autores principales: Liu, Li, Liu, Shaohua, Hao, Meng, Hu, Song, Yu, Tian, Yang, Yunkai, Liu, Zhelong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559880/
https://www.ncbi.nlm.nih.gov/pubmed/37810784
http://dx.doi.org/10.7717/peerj.16055
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author Liu, Li
Liu, Shaohua
Hao, Meng
Hu, Song
Yu, Tian
Yang, Yunkai
Liu, Zhelong
author_facet Liu, Li
Liu, Shaohua
Hao, Meng
Hu, Song
Yu, Tian
Yang, Yunkai
Liu, Zhelong
author_sort Liu, Li
collection PubMed
description BACKGROUND: Low muscle mass/sarcopenia has been associated with poor prognosis in many diseases, but its clinical significance in pyogenic liver abscess (PLA) remains unclear. The purpose of this study is to investigate the relationship between muscle mass and prognosis of patients with PLA. METHODS: A total of 154 adult patients with PLA hospitalized at Tongji Hospital (Wuhan, Hubei, China) between October 2011 and June 2021 were included in this retrospective analysis. Muscle-fat related indicators were measured by computed tomography (CT) images at the third lumbar vertebra (L3) level. The data of patients between the sarcopenia group and non-sarcopenia group were compared. Multivariate logistic regression and receiver operating characteristic (ROC) curve analyses were performed. RESULTS: The skeletal muscle index (SMI) was independently associated with adverse outcomes (95% CI [0.649–0.954], P = 0.015) of PLA in multivariate logistic regression analysis. This conclusion held true in sex-specific subgroup analysis. ROC analysis indicated that SMI may predict adverse outcomes in both male (area under the ROC curve [AUC], 0.718; cut-off, 52.59; P < 0.001) and female (AUC, 0.714; cut-off, 38.39; P = 0.017) patient populations. CONCLUSIONS: Sarcopenia serves as an independent risk factor for poor prognosis in PLA and patients with sarcopenia may be more prone to adverse outcomes.
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spelling pubmed-105598802023-10-08 Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess Liu, Li Liu, Shaohua Hao, Meng Hu, Song Yu, Tian Yang, Yunkai Liu, Zhelong PeerJ Diabetes and Endocrinology BACKGROUND: Low muscle mass/sarcopenia has been associated with poor prognosis in many diseases, but its clinical significance in pyogenic liver abscess (PLA) remains unclear. The purpose of this study is to investigate the relationship between muscle mass and prognosis of patients with PLA. METHODS: A total of 154 adult patients with PLA hospitalized at Tongji Hospital (Wuhan, Hubei, China) between October 2011 and June 2021 were included in this retrospective analysis. Muscle-fat related indicators were measured by computed tomography (CT) images at the third lumbar vertebra (L3) level. The data of patients between the sarcopenia group and non-sarcopenia group were compared. Multivariate logistic regression and receiver operating characteristic (ROC) curve analyses were performed. RESULTS: The skeletal muscle index (SMI) was independently associated with adverse outcomes (95% CI [0.649–0.954], P = 0.015) of PLA in multivariate logistic regression analysis. This conclusion held true in sex-specific subgroup analysis. ROC analysis indicated that SMI may predict adverse outcomes in both male (area under the ROC curve [AUC], 0.718; cut-off, 52.59; P < 0.001) and female (AUC, 0.714; cut-off, 38.39; P = 0.017) patient populations. CONCLUSIONS: Sarcopenia serves as an independent risk factor for poor prognosis in PLA and patients with sarcopenia may be more prone to adverse outcomes. PeerJ Inc. 2023-10-04 /pmc/articles/PMC10559880/ /pubmed/37810784 http://dx.doi.org/10.7717/peerj.16055 Text en ©2023 Liu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Diabetes and Endocrinology
Liu, Li
Liu, Shaohua
Hao, Meng
Hu, Song
Yu, Tian
Yang, Yunkai
Liu, Zhelong
Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess
title Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess
title_full Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess
title_fullStr Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess
title_full_unstemmed Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess
title_short Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess
title_sort sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess
topic Diabetes and Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559880/
https://www.ncbi.nlm.nih.gov/pubmed/37810784
http://dx.doi.org/10.7717/peerj.16055
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