Fabrication of pH-dependent solid dispersion for oral colon-targeted delivery of notoginsenoside R1 and its protective effects on ulcerative colitis mice()

Notoginsenoside R1 (R1), which originated from the rhizomes and roots of Panax notoginseng, is classified as a Biopharmaceutical Classification System class III drug with good solubility but poor oral absorption. Although R1 can alleviate the inflammation of dextran sulfate sodium (DSS)-induced coli...

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Detalles Bibliográficos
Autores principales: Tie, Hongyun, Wang, Yaru, Shang, Yunxia, Li, Manlin, Wei, Xiaohui, Wang, Zhengtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560026/
https://www.ncbi.nlm.nih.gov/pubmed/37809823
http://dx.doi.org/10.1016/j.heliyon.2023.e20280

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