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Factors associated with gastrointestinal dysmotility in critically ill patients

Critical illness may disrupt nutritional, protective, immune, and endocrine functions of the gastrointestinal tract, leading to a state of gastrointestinal dysmotility. We aimed to identify factors associated with the occurrence of gastrointestinal dysmotility in critically ill patients. A cross-sec...

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Autores principales: Petrović, Nemanja, Žunić, Miodrag, Pejčić, Ana, Milosavljević, Miloš, Janković, Slobodan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560032/
https://www.ncbi.nlm.nih.gov/pubmed/37808163
http://dx.doi.org/10.1515/med-2023-0820
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author Petrović, Nemanja
Žunić, Miodrag
Pejčić, Ana
Milosavljević, Miloš
Janković, Slobodan
author_facet Petrović, Nemanja
Žunić, Miodrag
Pejčić, Ana
Milosavljević, Miloš
Janković, Slobodan
author_sort Petrović, Nemanja
collection PubMed
description Critical illness may disrupt nutritional, protective, immune, and endocrine functions of the gastrointestinal tract, leading to a state of gastrointestinal dysmotility. We aimed to identify factors associated with the occurrence of gastrointestinal dysmotility in critically ill patients. A cross-sectional retrospective study was conducted, using patient files as a source of data. The study included 185 critically ill patients treated in the intensive care unit of the University Clinical Center, Kragujevac, Serbia, from January 1, 2016, to January 1, 2022. Significant risk factors associated with some form of gastrointestinal dysmotility were acute kidney injury (with paralytic ileus, nausea, vomiting, and constipation), recent abdominal surgery (with ileus, nausea, vomiting, and constipation), mechanical ventilation (with ileus, and nausea), age (with ileus and constipation), and use of certain medication such as opioids (with ileus, gastro-esophageal reflux, nausea, vomiting, and constipation), antidepressants (with ileus, nausea, and vomiting), and antidiabetics (with ileus). On the other hand, Charlson comorbidity index had divergent effects, depending on the form of gastrointestinal dysmotility: it increased the risk of gastro-esophageal reflux but protected against ileus, nausea, and vomiting. In clonclusion, recognition of factors associated with gastrointestinal dysmotility should initiate preventative measures and, thus, accelerate the recovery of critically ill.
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spelling pubmed-105600322023-10-08 Factors associated with gastrointestinal dysmotility in critically ill patients Petrović, Nemanja Žunić, Miodrag Pejčić, Ana Milosavljević, Miloš Janković, Slobodan Open Med (Wars) Research Article Critical illness may disrupt nutritional, protective, immune, and endocrine functions of the gastrointestinal tract, leading to a state of gastrointestinal dysmotility. We aimed to identify factors associated with the occurrence of gastrointestinal dysmotility in critically ill patients. A cross-sectional retrospective study was conducted, using patient files as a source of data. The study included 185 critically ill patients treated in the intensive care unit of the University Clinical Center, Kragujevac, Serbia, from January 1, 2016, to January 1, 2022. Significant risk factors associated with some form of gastrointestinal dysmotility were acute kidney injury (with paralytic ileus, nausea, vomiting, and constipation), recent abdominal surgery (with ileus, nausea, vomiting, and constipation), mechanical ventilation (with ileus, and nausea), age (with ileus and constipation), and use of certain medication such as opioids (with ileus, gastro-esophageal reflux, nausea, vomiting, and constipation), antidepressants (with ileus, nausea, and vomiting), and antidiabetics (with ileus). On the other hand, Charlson comorbidity index had divergent effects, depending on the form of gastrointestinal dysmotility: it increased the risk of gastro-esophageal reflux but protected against ileus, nausea, and vomiting. In clonclusion, recognition of factors associated with gastrointestinal dysmotility should initiate preventative measures and, thus, accelerate the recovery of critically ill. De Gruyter 2023-10-05 /pmc/articles/PMC10560032/ /pubmed/37808163 http://dx.doi.org/10.1515/med-2023-0820 Text en © 2023 the author(s), published by De Gruyter https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Research Article
Petrović, Nemanja
Žunić, Miodrag
Pejčić, Ana
Milosavljević, Miloš
Janković, Slobodan
Factors associated with gastrointestinal dysmotility in critically ill patients
title Factors associated with gastrointestinal dysmotility in critically ill patients
title_full Factors associated with gastrointestinal dysmotility in critically ill patients
title_fullStr Factors associated with gastrointestinal dysmotility in critically ill patients
title_full_unstemmed Factors associated with gastrointestinal dysmotility in critically ill patients
title_short Factors associated with gastrointestinal dysmotility in critically ill patients
title_sort factors associated with gastrointestinal dysmotility in critically ill patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560032/
https://www.ncbi.nlm.nih.gov/pubmed/37808163
http://dx.doi.org/10.1515/med-2023-0820
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