Integrin signaling is critical for myeloid-mediated support of T-cell acute lymphoblastic leukemia

We previously found that T-cell acute lymphoblastic leukemia (T-ALL) requires support from tumor-associated myeloid cells, which activate Insulin Like Growth Factor 1 Receptor (IGF1R) signaling in leukemic blasts. However, IGF1 is not sufficient to sustain T-ALL in vitro, implicating additional myel...

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Detalles Bibliográficos
Autores principales: Lyu, Aram, Humphrey, Ryan S., Nam, Seo Hee, Durham, Tyler A., Hu, Zicheng, Arasappan, Dhivya, Horton, Terzah M., Ehrlich, Lauren I. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560206/
https://www.ncbi.nlm.nih.gov/pubmed/37805579
http://dx.doi.org/10.1038/s41467-023-41925-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560206/
https://www.ncbi.nlm.nih.gov/pubmed/37805579
http://dx.doi.org/10.1038/s41467-023-41925-z

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