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Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold

Heart valve disease is a major cause of mortality and morbidity worldwide with no effective medical therapy and no ideal valve substitute emulating the extremely sophisticated functions of a living heart valve. These functions influence survival and quality of life. This has stimulated extensive att...

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Autores principales: Yacoub, Magdi H., Tseng, Yuan-Tsan, Kluin, Jolanda, Vis, Annemijn, Stock, Ulrich, Smail, Hassiba, Sarathchandra, Padmini, Aikawa, Elena, El-Nashar, Hussam, Chester, Adrian H., Shehata, Nairouz, Nagy, Mohamed, El-sawy, Amr, Li, Wei, Burriesci, Gaetano, Salmonsmith, Jacob, Romeih, Soha, Latif, Najma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560219/
https://www.ncbi.nlm.nih.gov/pubmed/37805576
http://dx.doi.org/10.1038/s42003-023-05383-z
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author Yacoub, Magdi H.
Tseng, Yuan-Tsan
Kluin, Jolanda
Vis, Annemijn
Stock, Ulrich
Smail, Hassiba
Sarathchandra, Padmini
Aikawa, Elena
El-Nashar, Hussam
Chester, Adrian H.
Shehata, Nairouz
Nagy, Mohamed
El-sawy, Amr
Li, Wei
Burriesci, Gaetano
Salmonsmith, Jacob
Romeih, Soha
Latif, Najma
author_facet Yacoub, Magdi H.
Tseng, Yuan-Tsan
Kluin, Jolanda
Vis, Annemijn
Stock, Ulrich
Smail, Hassiba
Sarathchandra, Padmini
Aikawa, Elena
El-Nashar, Hussam
Chester, Adrian H.
Shehata, Nairouz
Nagy, Mohamed
El-sawy, Amr
Li, Wei
Burriesci, Gaetano
Salmonsmith, Jacob
Romeih, Soha
Latif, Najma
author_sort Yacoub, Magdi H.
collection PubMed
description Heart valve disease is a major cause of mortality and morbidity worldwide with no effective medical therapy and no ideal valve substitute emulating the extremely sophisticated functions of a living heart valve. These functions influence survival and quality of life. This has stimulated extensive attempts at tissue engineering “living” heart valves. These attempts utilised combinations of allogeneic/ autologous cells and biological scaffolds with practical, regulatory, and ethical issues. In situ regeneration depends on scaffolds that attract, house and instruct cells and promote connective tissue formation. We describe a surgical, tissue-engineered, anatomically precise, novel off-the-shelf, acellular, synthetic scaffold inducing a rapid process of morphogenesis involving relevant cell types, extracellular matrix, regulatory elements including nerves and humoral components. This process relies on specific material characteristics, design and “morphodynamism”.
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spelling pubmed-105602192023-10-09 Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold Yacoub, Magdi H. Tseng, Yuan-Tsan Kluin, Jolanda Vis, Annemijn Stock, Ulrich Smail, Hassiba Sarathchandra, Padmini Aikawa, Elena El-Nashar, Hussam Chester, Adrian H. Shehata, Nairouz Nagy, Mohamed El-sawy, Amr Li, Wei Burriesci, Gaetano Salmonsmith, Jacob Romeih, Soha Latif, Najma Commun Biol Article Heart valve disease is a major cause of mortality and morbidity worldwide with no effective medical therapy and no ideal valve substitute emulating the extremely sophisticated functions of a living heart valve. These functions influence survival and quality of life. This has stimulated extensive attempts at tissue engineering “living” heart valves. These attempts utilised combinations of allogeneic/ autologous cells and biological scaffolds with practical, regulatory, and ethical issues. In situ regeneration depends on scaffolds that attract, house and instruct cells and promote connective tissue formation. We describe a surgical, tissue-engineered, anatomically precise, novel off-the-shelf, acellular, synthetic scaffold inducing a rapid process of morphogenesis involving relevant cell types, extracellular matrix, regulatory elements including nerves and humoral components. This process relies on specific material characteristics, design and “morphodynamism”. Nature Publishing Group UK 2023-10-07 /pmc/articles/PMC10560219/ /pubmed/37805576 http://dx.doi.org/10.1038/s42003-023-05383-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yacoub, Magdi H.
Tseng, Yuan-Tsan
Kluin, Jolanda
Vis, Annemijn
Stock, Ulrich
Smail, Hassiba
Sarathchandra, Padmini
Aikawa, Elena
El-Nashar, Hussam
Chester, Adrian H.
Shehata, Nairouz
Nagy, Mohamed
El-sawy, Amr
Li, Wei
Burriesci, Gaetano
Salmonsmith, Jacob
Romeih, Soha
Latif, Najma
Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold
title Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold
title_full Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold
title_fullStr Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold
title_full_unstemmed Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold
title_short Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold
title_sort valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560219/
https://www.ncbi.nlm.nih.gov/pubmed/37805576
http://dx.doi.org/10.1038/s42003-023-05383-z
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