Muscarinic receptor agonist-induced βPix binding to β-catenin promotes colon neoplasia

M(3) muscarinic receptors (M(3)R) modulate β-catenin signaling and colon neoplasia. CDC42/RAC guanine nucleotide exchange factor, βPix, binds to β-catenin in colon cancer cells, augmenting β-catenin transcriptional activity. Using in silico, in vitro, and in vivo approaches, we explored whether thes...

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Detalles Bibliográficos
Autores principales: Cheng, Kunrong, Chahdi, Ahmed, Larabee, Shannon M., Tolaymat, Mazen, Sundel, Margaret H., Drachenberg, Cinthia B., Zhan, Min, Hu, Shien, Said, Anan H., Shang, Aaron C., Xie, Guofeng, Alizadeh, Madeline, Moura, Natalia Sampaio, Bafford, Andrea C., Williams, Richelle T., Hanna, Nader N., Raufman, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560271/
https://www.ncbi.nlm.nih.gov/pubmed/37805544
http://dx.doi.org/10.1038/s41598-023-44158-8

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