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Serum adiponectin in Indian women with polycystic ovary syndrome
Poly Cystic Ovary Syndrome (PCOS) is mainly characterised by reproductive hormonal imbalance and increased androgen levels, ovulatory dysfunction and polycystic appearing ovaries on ultrasonography. The obesity is common factor to cause PCOS and this adipocytokines play an important role to cause ob...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Biomedical Informatics
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560301/ https://www.ncbi.nlm.nih.gov/pubmed/37814678 http://dx.doi.org/10.6026/97320630019206 |
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author | Rajendra, Aishwarya Thilak, Swathi Ganesh, Veluri |
author_facet | Rajendra, Aishwarya Thilak, Swathi Ganesh, Veluri |
author_sort | Rajendra, Aishwarya |
collection | PubMed |
description | Poly Cystic Ovary Syndrome (PCOS) is mainly characterised by reproductive hormonal imbalance and increased androgen levels, ovulatory dysfunction and polycystic appearing ovaries on ultrasonography. The obesity is common factor to cause PCOS and this adipocytokines play an important role to cause obesity related disorders. Hence, the present study aimed to evaluate the role of adiponectin in women with PCOS compared them with healthy controls. This case control study included total eighty (80) subjects out of this fourty subjects with PCOS and remaining fourty (40) age and body mass index matched healthy controls. The fasting, post parandial blood sugars, glycated haemoglobin, lipid profile and adiponectin levels were measured and data was recorded. There was a significantly elevated levels of total cholesterol, triacylglycerol, very low density lipoprotein, low density lipoprotein (p = 0.0001**) and there were no significant levels of fasting and post parandial blood sugars, glycated haemoglobin levels were observed in women with PCOS than in controls. Additionally, we also observed significantly decreased levels of high density lipoprotein and adiponectin in women with PCOS when compared to healthy controls (p = 0.0001**). The adiponectin shown a positive correlation with age, high density lipoprotein and negative correlation with total cholesterol, triacylglycerol, very low density lipoprotein and low density lipoprotein (p = 0.0001**). The altered adiponectin levels in polycystic ovary syndrome appear to form an important link between obesity and the complications of PCOS. |
format | Online Article Text |
id | pubmed-10560301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Biomedical Informatics |
record_format | MEDLINE/PubMed |
spelling | pubmed-105603012023-10-09 Serum adiponectin in Indian women with polycystic ovary syndrome Rajendra, Aishwarya Thilak, Swathi Ganesh, Veluri Bioinformation Research Article Poly Cystic Ovary Syndrome (PCOS) is mainly characterised by reproductive hormonal imbalance and increased androgen levels, ovulatory dysfunction and polycystic appearing ovaries on ultrasonography. The obesity is common factor to cause PCOS and this adipocytokines play an important role to cause obesity related disorders. Hence, the present study aimed to evaluate the role of adiponectin in women with PCOS compared them with healthy controls. This case control study included total eighty (80) subjects out of this fourty subjects with PCOS and remaining fourty (40) age and body mass index matched healthy controls. The fasting, post parandial blood sugars, glycated haemoglobin, lipid profile and adiponectin levels were measured and data was recorded. There was a significantly elevated levels of total cholesterol, triacylglycerol, very low density lipoprotein, low density lipoprotein (p = 0.0001**) and there were no significant levels of fasting and post parandial blood sugars, glycated haemoglobin levels were observed in women with PCOS than in controls. Additionally, we also observed significantly decreased levels of high density lipoprotein and adiponectin in women with PCOS when compared to healthy controls (p = 0.0001**). The adiponectin shown a positive correlation with age, high density lipoprotein and negative correlation with total cholesterol, triacylglycerol, very low density lipoprotein and low density lipoprotein (p = 0.0001**). The altered adiponectin levels in polycystic ovary syndrome appear to form an important link between obesity and the complications of PCOS. Biomedical Informatics 2023-02-28 /pmc/articles/PMC10560301/ /pubmed/37814678 http://dx.doi.org/10.6026/97320630019206 Text en © 2023 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |
spellingShingle | Research Article Rajendra, Aishwarya Thilak, Swathi Ganesh, Veluri Serum adiponectin in Indian women with polycystic ovary syndrome |
title | Serum adiponectin in Indian women with polycystic ovary syndrome |
title_full | Serum adiponectin in Indian women with polycystic ovary syndrome |
title_fullStr | Serum adiponectin in Indian women with polycystic ovary syndrome |
title_full_unstemmed | Serum adiponectin in Indian women with polycystic ovary syndrome |
title_short | Serum adiponectin in Indian women with polycystic ovary syndrome |
title_sort | serum adiponectin in indian women with polycystic ovary syndrome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560301/ https://www.ncbi.nlm.nih.gov/pubmed/37814678 http://dx.doi.org/10.6026/97320630019206 |
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