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Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation
BACKGROUND: The aim of the study was to explore the mutual relationship between oxidative stress, inflammation and metabolic biomarkers in subjects with prediabetes (PRE), newly diagnosed type 2 diabetes patients (NT2D) and overt type 2 diabetes (T2D) using principal component analysis (PCA) as a th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560504/ https://www.ncbi.nlm.nih.gov/pubmed/37814622 http://dx.doi.org/10.5937/jomb0-39636 |
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author | Malenica, Maja Klisić, Aleksandra Meseldžić, Neven Dujić, Tanja Bego, Tamer Kotur-Stevuljević, Jelena |
author_facet | Malenica, Maja Klisić, Aleksandra Meseldžić, Neven Dujić, Tanja Bego, Tamer Kotur-Stevuljević, Jelena |
author_sort | Malenica, Maja |
collection | PubMed |
description | BACKGROUND: The aim of the study was to explore the mutual relationship between oxidative stress, inflammation and metabolic biomarkers in subjects with prediabetes (PRE), newly diagnosed type 2 diabetes patients (NT2D) and overt type 2 diabetes (T2D) using principal component analysis (PCA) as a thorough statistical approach. METHODS: Glycated hemoglobin, lipid parameters, inflammation (IL-6, CRP and fibrinogen) and oxidative stress markers pro-oxidants (AOPP, PAB, TOS) and antioxidants (PON1, tSHG, TAS) were measured. PCA was applied to explore the factors that the most strongly influenced glucoregulation. RESULTS: A total of 278 subjects were (i.e., 37 PRE, 42 NT2D and 99 T2D) were compared with 100 healthy subjects as a control group (CG). PCA emphasized 4 different factors explaining 49% of the variance of the tested parameters: oxidative stress-dyslipidemia related factor (with positive loading of TG and tSHG, and with negative loading of HDL-c and TAS), dyslipidaemia related factor (i.e., total cholesterol and LDL-c, both with positive loading), Anthropometric related factor (i.e., waist and hip circumference, both with positive loading) and oxidative stressInflammation related factor (i.e., PAB, fibrinogen, and CRP all with positive loading). Out of these 4 factors, only oxidative stress - dyslipidaemia related factor showed a significant predictive capability towards poor glucoregulation. An increase in this factor by one unit showed a 1.6 times higher probability for poor glucoregulation. CONCLUSIONS: Redox imbalance (determined with lower TAS and higher tSHG), in addition to higher TG and lower HDLc was associated with poor glucoregulation. |
format | Online Article Text |
id | pubmed-10560504 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Society of Medical Biochemists of Serbia, Belgrade |
record_format | MEDLINE/PubMed |
spelling | pubmed-105605042023-10-09 Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation Malenica, Maja Klisić, Aleksandra Meseldžić, Neven Dujić, Tanja Bego, Tamer Kotur-Stevuljević, Jelena J Med Biochem Original Paper BACKGROUND: The aim of the study was to explore the mutual relationship between oxidative stress, inflammation and metabolic biomarkers in subjects with prediabetes (PRE), newly diagnosed type 2 diabetes patients (NT2D) and overt type 2 diabetes (T2D) using principal component analysis (PCA) as a thorough statistical approach. METHODS: Glycated hemoglobin, lipid parameters, inflammation (IL-6, CRP and fibrinogen) and oxidative stress markers pro-oxidants (AOPP, PAB, TOS) and antioxidants (PON1, tSHG, TAS) were measured. PCA was applied to explore the factors that the most strongly influenced glucoregulation. RESULTS: A total of 278 subjects were (i.e., 37 PRE, 42 NT2D and 99 T2D) were compared with 100 healthy subjects as a control group (CG). PCA emphasized 4 different factors explaining 49% of the variance of the tested parameters: oxidative stress-dyslipidemia related factor (with positive loading of TG and tSHG, and with negative loading of HDL-c and TAS), dyslipidaemia related factor (i.e., total cholesterol and LDL-c, both with positive loading), Anthropometric related factor (i.e., waist and hip circumference, both with positive loading) and oxidative stressInflammation related factor (i.e., PAB, fibrinogen, and CRP all with positive loading). Out of these 4 factors, only oxidative stress - dyslipidaemia related factor showed a significant predictive capability towards poor glucoregulation. An increase in this factor by one unit showed a 1.6 times higher probability for poor glucoregulation. CONCLUSIONS: Redox imbalance (determined with lower TAS and higher tSHG), in addition to higher TG and lower HDLc was associated with poor glucoregulation. Society of Medical Biochemists of Serbia, Belgrade 2023-08-25 2023-08-25 /pmc/articles/PMC10560504/ /pubmed/37814622 http://dx.doi.org/10.5937/jomb0-39636 Text en 2023 Maja Malenica, Aleksandra Klisić, Neven Meseldžić, Tanja Dujić, Tamer Bego, Jelena Kotur-Stevuljević, published by CEON/CEES https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License. |
spellingShingle | Original Paper Malenica, Maja Klisić, Aleksandra Meseldžić, Neven Dujić, Tanja Bego, Tamer Kotur-Stevuljević, Jelena Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation |
title | Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation |
title_full | Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation |
title_fullStr | Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation |
title_full_unstemmed | Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation |
title_short | Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation |
title_sort | principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560504/ https://www.ncbi.nlm.nih.gov/pubmed/37814622 http://dx.doi.org/10.5937/jomb0-39636 |
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