Cargando…

Vitamin D deficiency in relation with the systemic and central inflammation during multiple sclerosis

BACKGROUND: During the last decade, vitamin D (VitD) has become a topic of interest in immune regulation, especially in multiple sclerosis (MS) disease. Amongst the wide range of effects reported for this vitamin on the immune system, a regulatory role on cytokines production has been described. Our...

Descripción completa

Detalles Bibliográficos
Autores principales: Feki, Sawsan, Naifar, Manel, Dammak, Mariem, Majdoub, Sabrina, Sakka, Salma, Ben, Ali Yesmine, Hachicha, Hend, Mhiri, Chokri, Ayadi, Fatma, Masmoudi, Hatem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Medical Biochemists of Serbia, Belgrade 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560505/
https://www.ncbi.nlm.nih.gov/pubmed/37814621
http://dx.doi.org/10.5937/jomb0-37676
_version_ 1785117745570906112
author Feki, Sawsan
Naifar, Manel
Dammak, Mariem
Majdoub, Sabrina
Sakka, Salma
Ben, Ali Yesmine
Hachicha, Hend
Mhiri, Chokri
Ayadi, Fatma
Masmoudi, Hatem
author_facet Feki, Sawsan
Naifar, Manel
Dammak, Mariem
Majdoub, Sabrina
Sakka, Salma
Ben, Ali Yesmine
Hachicha, Hend
Mhiri, Chokri
Ayadi, Fatma
Masmoudi, Hatem
author_sort Feki, Sawsan
collection PubMed
description BACKGROUND: During the last decade, vitamin D (VitD) has become a topic of interest in immune regulation, especially in multiple sclerosis (MS) disease. Amongst the wide range of effects reported for this vitamin on the immune system, a regulatory role on cytokines production has been described. Our aim is to analyze the status of VitD and its correlation with the circulating inflammation and the intrathecal humoral response during MS. METHODS: We analyzed samples of 318 individuals: 108 MS patients and 210 controls. Determination of 25-(OH) VitD3 level in serum was made using electrochemiluminescence method. Circulating inflammatory cytokines (IL-6, IL-8, IL-10, TNF-a, IL12p70 and IL-1b) were investigated using Cytometer Bead Array Technology. The central humoral response was characterized using CSF isofocusing test and IgG Index calculation. RESULTS: As expected, mean value of VitD was significantly lower in MS group (26 nmol/L) than in control group (34.75 nmol/L) (p=0.002), with a severe deficiency in 67% of MS patients. Mean value of VitD was significantly lower in MS female patients. Regarding cytokines, mean value of TNFa was significantly higher in MS patients with oligoclonal bands of IgG in the CSF. IL6 was positively correlated with IgG level in serum of MS patients. CONCLUSIONS: Our results support the association of VitD deficiency with MS, especially in female patients of our region. However, the vitamin level seems to not correlate with inflammatory cytokines nor with disability. Interestingly, TNFa and IL6 levels were correlated with the intrathecal synthesis of IgG and the circulating IgG level, respectively.
format Online
Article
Text
id pubmed-10560505
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Society of Medical Biochemists of Serbia, Belgrade
record_format MEDLINE/PubMed
spelling pubmed-105605052023-10-09 Vitamin D deficiency in relation with the systemic and central inflammation during multiple sclerosis Feki, Sawsan Naifar, Manel Dammak, Mariem Majdoub, Sabrina Sakka, Salma Ben, Ali Yesmine Hachicha, Hend Mhiri, Chokri Ayadi, Fatma Masmoudi, Hatem J Med Biochem Original Paper BACKGROUND: During the last decade, vitamin D (VitD) has become a topic of interest in immune regulation, especially in multiple sclerosis (MS) disease. Amongst the wide range of effects reported for this vitamin on the immune system, a regulatory role on cytokines production has been described. Our aim is to analyze the status of VitD and its correlation with the circulating inflammation and the intrathecal humoral response during MS. METHODS: We analyzed samples of 318 individuals: 108 MS patients and 210 controls. Determination of 25-(OH) VitD3 level in serum was made using electrochemiluminescence method. Circulating inflammatory cytokines (IL-6, IL-8, IL-10, TNF-a, IL12p70 and IL-1b) were investigated using Cytometer Bead Array Technology. The central humoral response was characterized using CSF isofocusing test and IgG Index calculation. RESULTS: As expected, mean value of VitD was significantly lower in MS group (26 nmol/L) than in control group (34.75 nmol/L) (p=0.002), with a severe deficiency in 67% of MS patients. Mean value of VitD was significantly lower in MS female patients. Regarding cytokines, mean value of TNFa was significantly higher in MS patients with oligoclonal bands of IgG in the CSF. IL6 was positively correlated with IgG level in serum of MS patients. CONCLUSIONS: Our results support the association of VitD deficiency with MS, especially in female patients of our region. However, the vitamin level seems to not correlate with inflammatory cytokines nor with disability. Interestingly, TNFa and IL6 levels were correlated with the intrathecal synthesis of IgG and the circulating IgG level, respectively. Society of Medical Biochemists of Serbia, Belgrade 2023-08-25 2023-08-25 /pmc/articles/PMC10560505/ /pubmed/37814621 http://dx.doi.org/10.5937/jomb0-37676 Text en 2023 Sawsan Feki, Manel Naifar, Mariem Dammak, Sabrina Majdoub, Salma Sakka, Ali Yesmine Ben, Hend Hachicha, Chokri Mhiri, Fatma Ayadi, Hatem Masmoudi, published by CEON/CEES https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License.
spellingShingle Original Paper
Feki, Sawsan
Naifar, Manel
Dammak, Mariem
Majdoub, Sabrina
Sakka, Salma
Ben, Ali Yesmine
Hachicha, Hend
Mhiri, Chokri
Ayadi, Fatma
Masmoudi, Hatem
Vitamin D deficiency in relation with the systemic and central inflammation during multiple sclerosis
title Vitamin D deficiency in relation with the systemic and central inflammation during multiple sclerosis
title_full Vitamin D deficiency in relation with the systemic and central inflammation during multiple sclerosis
title_fullStr Vitamin D deficiency in relation with the systemic and central inflammation during multiple sclerosis
title_full_unstemmed Vitamin D deficiency in relation with the systemic and central inflammation during multiple sclerosis
title_short Vitamin D deficiency in relation with the systemic and central inflammation during multiple sclerosis
title_sort vitamin d deficiency in relation with the systemic and central inflammation during multiple sclerosis
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560505/
https://www.ncbi.nlm.nih.gov/pubmed/37814621
http://dx.doi.org/10.5937/jomb0-37676
work_keys_str_mv AT fekisawsan vitaminddeficiencyinrelationwiththesystemicandcentralinflammationduringmultiplesclerosis
AT naifarmanel vitaminddeficiencyinrelationwiththesystemicandcentralinflammationduringmultiplesclerosis
AT dammakmariem vitaminddeficiencyinrelationwiththesystemicandcentralinflammationduringmultiplesclerosis
AT majdoubsabrina vitaminddeficiencyinrelationwiththesystemicandcentralinflammationduringmultiplesclerosis
AT sakkasalma vitaminddeficiencyinrelationwiththesystemicandcentralinflammationduringmultiplesclerosis
AT benaliyesmine vitaminddeficiencyinrelationwiththesystemicandcentralinflammationduringmultiplesclerosis
AT hachichahend vitaminddeficiencyinrelationwiththesystemicandcentralinflammationduringmultiplesclerosis
AT mhirichokri vitaminddeficiencyinrelationwiththesystemicandcentralinflammationduringmultiplesclerosis
AT ayadifatma vitaminddeficiencyinrelationwiththesystemicandcentralinflammationduringmultiplesclerosis
AT masmoudihatem vitaminddeficiencyinrelationwiththesystemicandcentralinflammationduringmultiplesclerosis