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Bilateral Avascular Necrosis of the Femoral Heads Secondary to Familial Hyperlipidemia

Avascular necrosis (AVN) is a progressive disease characterized by bone death secondary to an interruption of the relevant vascular supply. While it is most common in pediatrics and later adulthood, it can occur at any age. This case describes a previously healthy man in his mid-twenties who present...

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Autores principales: Fusillo, Thomas F, Nguyen, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560536/
https://www.ncbi.nlm.nih.gov/pubmed/37814725
http://dx.doi.org/10.7759/cureus.44910
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author Fusillo, Thomas F
Nguyen, Michael
author_facet Fusillo, Thomas F
Nguyen, Michael
author_sort Fusillo, Thomas F
collection PubMed
description Avascular necrosis (AVN) is a progressive disease characterized by bone death secondary to an interruption of the relevant vascular supply. While it is most common in pediatrics and later adulthood, it can occur at any age. This case describes a previously healthy man in his mid-twenties who presented with worsening hip pain. Imaging, including X-ray and magnetic resonance, revealed severe marrow edema and early collapse of the femoral head. The patient was also found to have a severely elevated low-density lipoprotein level, leading to the diagnosis of AVN due to familial hyperlipidemia. He received a total hip arthroplasty and was started on high-intensity statin therapy. This case highlights the importance of considering AVN in the young adult population with hip pain as well as the appropriate workup and treatment.
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spelling pubmed-105605362023-10-09 Bilateral Avascular Necrosis of the Femoral Heads Secondary to Familial Hyperlipidemia Fusillo, Thomas F Nguyen, Michael Cureus Orthopedics Avascular necrosis (AVN) is a progressive disease characterized by bone death secondary to an interruption of the relevant vascular supply. While it is most common in pediatrics and later adulthood, it can occur at any age. This case describes a previously healthy man in his mid-twenties who presented with worsening hip pain. Imaging, including X-ray and magnetic resonance, revealed severe marrow edema and early collapse of the femoral head. The patient was also found to have a severely elevated low-density lipoprotein level, leading to the diagnosis of AVN due to familial hyperlipidemia. He received a total hip arthroplasty and was started on high-intensity statin therapy. This case highlights the importance of considering AVN in the young adult population with hip pain as well as the appropriate workup and treatment. Cureus 2023-09-08 /pmc/articles/PMC10560536/ /pubmed/37814725 http://dx.doi.org/10.7759/cureus.44910 Text en Copyright © 2023, Fusillo et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Orthopedics
Fusillo, Thomas F
Nguyen, Michael
Bilateral Avascular Necrosis of the Femoral Heads Secondary to Familial Hyperlipidemia
title Bilateral Avascular Necrosis of the Femoral Heads Secondary to Familial Hyperlipidemia
title_full Bilateral Avascular Necrosis of the Femoral Heads Secondary to Familial Hyperlipidemia
title_fullStr Bilateral Avascular Necrosis of the Femoral Heads Secondary to Familial Hyperlipidemia
title_full_unstemmed Bilateral Avascular Necrosis of the Femoral Heads Secondary to Familial Hyperlipidemia
title_short Bilateral Avascular Necrosis of the Femoral Heads Secondary to Familial Hyperlipidemia
title_sort bilateral avascular necrosis of the femoral heads secondary to familial hyperlipidemia
topic Orthopedics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560536/
https://www.ncbi.nlm.nih.gov/pubmed/37814725
http://dx.doi.org/10.7759/cureus.44910
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