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Generation and propagation of bursts of activity in the developing basal ganglia
The neonatal brain is characterized by intermittent bursts of oscillatory activity interspersed by relative silence. Although well-characterized for many cortical areas, to what extent these propagate and interact with subcortical brain areas is largely unknown. Here, early network activity was reco...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560579/ https://www.ncbi.nlm.nih.gov/pubmed/37615347 http://dx.doi.org/10.1093/cercor/bhad307 |
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author | Klavinskis-Whiting, Sebastian Bitzenhofer, Sebastian Hanganu-Opatz, Ileana Ellender, Tommas |
author_facet | Klavinskis-Whiting, Sebastian Bitzenhofer, Sebastian Hanganu-Opatz, Ileana Ellender, Tommas |
author_sort | Klavinskis-Whiting, Sebastian |
collection | PubMed |
description | The neonatal brain is characterized by intermittent bursts of oscillatory activity interspersed by relative silence. Although well-characterized for many cortical areas, to what extent these propagate and interact with subcortical brain areas is largely unknown. Here, early network activity was recorded from the developing basal ganglia, including motor/somatosensory cortex, dorsal striatum, and intralaminar thalamus, during the first postnatal weeks in mice. An unsupervised detection and classification method revealed two main classes of bursting activity, namely spindle bursts and nested gamma spindle bursts, characterized by oscillatory activity at ~ 10 and ~ 30 Hz frequencies, respectively. These were reliably identified across all three brain regions and exhibited region-specific differences in their structural, spectral, and developmental characteristics. Bursts of the same type often co-occurred in different brain regions and coherence and cross-correlation analyses reveal dynamic developmental changes in their interactions. The strongest interactions were seen for cortex and striatum, from the first postnatal week onwards, and cortex appeared to drive burst events in subcortical regions. Together, these results provide the first detailed description of early network activity within the developing basal ganglia and suggest that cortex is one of the main drivers of activity in downstream nuclei during this postnatal period. |
format | Online Article Text |
id | pubmed-10560579 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-105605792023-10-09 Generation and propagation of bursts of activity in the developing basal ganglia Klavinskis-Whiting, Sebastian Bitzenhofer, Sebastian Hanganu-Opatz, Ileana Ellender, Tommas Cereb Cortex Original Article The neonatal brain is characterized by intermittent bursts of oscillatory activity interspersed by relative silence. Although well-characterized for many cortical areas, to what extent these propagate and interact with subcortical brain areas is largely unknown. Here, early network activity was recorded from the developing basal ganglia, including motor/somatosensory cortex, dorsal striatum, and intralaminar thalamus, during the first postnatal weeks in mice. An unsupervised detection and classification method revealed two main classes of bursting activity, namely spindle bursts and nested gamma spindle bursts, characterized by oscillatory activity at ~ 10 and ~ 30 Hz frequencies, respectively. These were reliably identified across all three brain regions and exhibited region-specific differences in their structural, spectral, and developmental characteristics. Bursts of the same type often co-occurred in different brain regions and coherence and cross-correlation analyses reveal dynamic developmental changes in their interactions. The strongest interactions were seen for cortex and striatum, from the first postnatal week onwards, and cortex appeared to drive burst events in subcortical regions. Together, these results provide the first detailed description of early network activity within the developing basal ganglia and suggest that cortex is one of the main drivers of activity in downstream nuclei during this postnatal period. Oxford University Press 2023-08-23 /pmc/articles/PMC10560579/ /pubmed/37615347 http://dx.doi.org/10.1093/cercor/bhad307 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Klavinskis-Whiting, Sebastian Bitzenhofer, Sebastian Hanganu-Opatz, Ileana Ellender, Tommas Generation and propagation of bursts of activity in the developing basal ganglia |
title | Generation and propagation of bursts of activity in the developing basal ganglia |
title_full | Generation and propagation of bursts of activity in the developing basal ganglia |
title_fullStr | Generation and propagation of bursts of activity in the developing basal ganglia |
title_full_unstemmed | Generation and propagation of bursts of activity in the developing basal ganglia |
title_short | Generation and propagation of bursts of activity in the developing basal ganglia |
title_sort | generation and propagation of bursts of activity in the developing basal ganglia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560579/ https://www.ncbi.nlm.nih.gov/pubmed/37615347 http://dx.doi.org/10.1093/cercor/bhad307 |
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