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Dense attention network identifies EEG abnormalities during working memory performance of patients with schizophrenia
INTRODUCTION: Patients with schizophrenia typically exhibit deficits in working memory (WM) associated with abnormalities in brain activity. Alterations in the encoding, maintenance and retrieval phases of sequential WM tasks are well established. However, due to the heterogeneity of symptoms and co...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560761/ https://www.ncbi.nlm.nih.gov/pubmed/37817830 http://dx.doi.org/10.3389/fpsyt.2023.1205119 |
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author | Perellón-Alfonso, Ruben Oblak, Aleš Kuclar, Matija Škrlj, Blaž Pileckyte, Indre Škodlar, Borut Pregelj, Peter Abellaneda-Pérez, Kilian Bartrés-Faz, David Repovš, Grega Bon, Jurij |
author_facet | Perellón-Alfonso, Ruben Oblak, Aleš Kuclar, Matija Škrlj, Blaž Pileckyte, Indre Škodlar, Borut Pregelj, Peter Abellaneda-Pérez, Kilian Bartrés-Faz, David Repovš, Grega Bon, Jurij |
author_sort | Perellón-Alfonso, Ruben |
collection | PubMed |
description | INTRODUCTION: Patients with schizophrenia typically exhibit deficits in working memory (WM) associated with abnormalities in brain activity. Alterations in the encoding, maintenance and retrieval phases of sequential WM tasks are well established. However, due to the heterogeneity of symptoms and complexity of its neurophysiological underpinnings, differential diagnosis remains a challenge. We conducted an electroencephalographic (EEG) study during a visual WM task in fifteen schizophrenia patients and fifteen healthy controls. We hypothesized that EEG abnormalities during the task could be identified, and patients successfully classified by an interpretable machine learning algorithm. METHODS: We tested a custom dense attention network (DAN) machine learning model to discriminate patients from control subjects and compared its performance with simpler and more commonly used machine learning models. Additionally, we analyzed behavioral performance, event-related EEG potentials, and time-frequency representations of the evoked responses to further characterize abnormalities in patients during WM. RESULTS: The DAN model was significantly accurate in discriminating patients from healthy controls, ACC = 0.69, SD = 0.05. There were no significant differences between groups, conditions, or their interaction in behavioral performance or event-related potentials. However, patients showed significantly lower alpha suppression in the task preparation, memory encoding, maintenance, and retrieval phases F(1,28) = 5.93, p = 0.022, η(2) = 0.149. Further analysis revealed that the two highest peaks in the attention value vector of the DAN model overlapped in time with the preparation and memory retrieval phases, as well as with two of the four significant time-frequency ROIs. DISCUSSION: These results highlight the potential utility of interpretable machine learning algorithms as an aid in diagnosis of schizophrenia and other psychiatric disorders presenting oscillatory abnormalities. |
format | Online Article Text |
id | pubmed-10560761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105607612023-10-10 Dense attention network identifies EEG abnormalities during working memory performance of patients with schizophrenia Perellón-Alfonso, Ruben Oblak, Aleš Kuclar, Matija Škrlj, Blaž Pileckyte, Indre Škodlar, Borut Pregelj, Peter Abellaneda-Pérez, Kilian Bartrés-Faz, David Repovš, Grega Bon, Jurij Front Psychiatry Psychiatry INTRODUCTION: Patients with schizophrenia typically exhibit deficits in working memory (WM) associated with abnormalities in brain activity. Alterations in the encoding, maintenance and retrieval phases of sequential WM tasks are well established. However, due to the heterogeneity of symptoms and complexity of its neurophysiological underpinnings, differential diagnosis remains a challenge. We conducted an electroencephalographic (EEG) study during a visual WM task in fifteen schizophrenia patients and fifteen healthy controls. We hypothesized that EEG abnormalities during the task could be identified, and patients successfully classified by an interpretable machine learning algorithm. METHODS: We tested a custom dense attention network (DAN) machine learning model to discriminate patients from control subjects and compared its performance with simpler and more commonly used machine learning models. Additionally, we analyzed behavioral performance, event-related EEG potentials, and time-frequency representations of the evoked responses to further characterize abnormalities in patients during WM. RESULTS: The DAN model was significantly accurate in discriminating patients from healthy controls, ACC = 0.69, SD = 0.05. There were no significant differences between groups, conditions, or their interaction in behavioral performance or event-related potentials. However, patients showed significantly lower alpha suppression in the task preparation, memory encoding, maintenance, and retrieval phases F(1,28) = 5.93, p = 0.022, η(2) = 0.149. Further analysis revealed that the two highest peaks in the attention value vector of the DAN model overlapped in time with the preparation and memory retrieval phases, as well as with two of the four significant time-frequency ROIs. DISCUSSION: These results highlight the potential utility of interpretable machine learning algorithms as an aid in diagnosis of schizophrenia and other psychiatric disorders presenting oscillatory abnormalities. Frontiers Media S.A. 2023-09-25 /pmc/articles/PMC10560761/ /pubmed/37817830 http://dx.doi.org/10.3389/fpsyt.2023.1205119 Text en Copyright © 2023 Perellón-Alfonso, Oblak, Kuclar, Škrlj, Pileckyte, Škodlar, Pregelj, Abellaneda-Pérez, Bartrés-Faz, Repovš and Bon. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Perellón-Alfonso, Ruben Oblak, Aleš Kuclar, Matija Škrlj, Blaž Pileckyte, Indre Škodlar, Borut Pregelj, Peter Abellaneda-Pérez, Kilian Bartrés-Faz, David Repovš, Grega Bon, Jurij Dense attention network identifies EEG abnormalities during working memory performance of patients with schizophrenia |
title | Dense attention network identifies EEG abnormalities during working memory performance of patients with schizophrenia |
title_full | Dense attention network identifies EEG abnormalities during working memory performance of patients with schizophrenia |
title_fullStr | Dense attention network identifies EEG abnormalities during working memory performance of patients with schizophrenia |
title_full_unstemmed | Dense attention network identifies EEG abnormalities during working memory performance of patients with schizophrenia |
title_short | Dense attention network identifies EEG abnormalities during working memory performance of patients with schizophrenia |
title_sort | dense attention network identifies eeg abnormalities during working memory performance of patients with schizophrenia |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560761/ https://www.ncbi.nlm.nih.gov/pubmed/37817830 http://dx.doi.org/10.3389/fpsyt.2023.1205119 |
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