Case report: Cardiac intimal sarcoma in a young child

Undifferentiated mesenchymal tumors from the intimal layer (intimal sarcomas) are rare within the ventricles and exceptional in children. A rare case of an intimal sarcoma located in the right ventricle in a young child is presented with need for urgent surgical resection due to mechanical flow obst...

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Autores principales: Verbeek, Sanne, Sciot, Raf, Debiec-Rychter, Maria, Labarque, Veerle, Meyns, Bart, Cools, Bjorn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560764/
https://www.ncbi.nlm.nih.gov/pubmed/37818167
http://dx.doi.org/10.3389/fped.2023.1238847
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author Verbeek, Sanne
Sciot, Raf
Debiec-Rychter, Maria
Labarque, Veerle
Meyns, Bart
Cools, Bjorn
author_facet Verbeek, Sanne
Sciot, Raf
Debiec-Rychter, Maria
Labarque, Veerle
Meyns, Bart
Cools, Bjorn
author_sort Verbeek, Sanne
collection PubMed
description Undifferentiated mesenchymal tumors from the intimal layer (intimal sarcomas) are rare within the ventricles and exceptional in children. A rare case of an intimal sarcoma located in the right ventricle in a young child is presented with need for urgent surgical resection due to mechanical flow obstruction. Tumor cells showed amplification of MDM2 gene and a homozygous loss of CDKN2A on 9p21. A review of the literature regarding primary cardiac malignancies and intimal sarcoma in children is provided.
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spelling pubmed-105607642023-10-10 Case report: Cardiac intimal sarcoma in a young child Verbeek, Sanne Sciot, Raf Debiec-Rychter, Maria Labarque, Veerle Meyns, Bart Cools, Bjorn Front Pediatr Pediatrics Undifferentiated mesenchymal tumors from the intimal layer (intimal sarcomas) are rare within the ventricles and exceptional in children. A rare case of an intimal sarcoma located in the right ventricle in a young child is presented with need for urgent surgical resection due to mechanical flow obstruction. Tumor cells showed amplification of MDM2 gene and a homozygous loss of CDKN2A on 9p21. A review of the literature regarding primary cardiac malignancies and intimal sarcoma in children is provided. Frontiers Media S.A. 2023-09-25 /pmc/articles/PMC10560764/ /pubmed/37818167 http://dx.doi.org/10.3389/fped.2023.1238847 Text en © 2023 Verbeek, Sciot, Debiec-Rychter, Labarque, Meyns and Cools. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Verbeek, Sanne
Sciot, Raf
Debiec-Rychter, Maria
Labarque, Veerle
Meyns, Bart
Cools, Bjorn
Case report: Cardiac intimal sarcoma in a young child
title Case report: Cardiac intimal sarcoma in a young child
title_full Case report: Cardiac intimal sarcoma in a young child
title_fullStr Case report: Cardiac intimal sarcoma in a young child
title_full_unstemmed Case report: Cardiac intimal sarcoma in a young child
title_short Case report: Cardiac intimal sarcoma in a young child
title_sort case report: cardiac intimal sarcoma in a young child
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560764/
https://www.ncbi.nlm.nih.gov/pubmed/37818167
http://dx.doi.org/10.3389/fped.2023.1238847
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