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Small cell carcinoma with neuroendocrine differentiation of subglottic larynx- a case report

Small cell cancer (SCC) is a neuroendocrine neoplasm, which is most frequently found in the lungs. Extrapulmonary location of SCC is rare and may involve 2.5-5% of SCCs. We present a case of a 31-year-old male patient with an extremely uncommon subglottic SCC. The patient was qualified for a radical...

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Autores principales: Becht, Rafał, Kiełbowski, Kajetan, Żychowska, Justyna, Dembowska, Wiktoria, Król, Małgorzata, Birkenfeld, Bożena, Owsiak, Mateusz, Lewandowska, Magdalena, Kubrak, Jadwiga, Amernik, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560848/
https://www.ncbi.nlm.nih.gov/pubmed/37817765
http://dx.doi.org/10.3389/fonc.2023.1222418
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author Becht, Rafał
Kiełbowski, Kajetan
Żychowska, Justyna
Dembowska, Wiktoria
Król, Małgorzata
Birkenfeld, Bożena
Owsiak, Mateusz
Lewandowska, Magdalena
Kubrak, Jadwiga
Amernik, Katarzyna
author_facet Becht, Rafał
Kiełbowski, Kajetan
Żychowska, Justyna
Dembowska, Wiktoria
Król, Małgorzata
Birkenfeld, Bożena
Owsiak, Mateusz
Lewandowska, Magdalena
Kubrak, Jadwiga
Amernik, Katarzyna
author_sort Becht, Rafał
collection PubMed
description Small cell cancer (SCC) is a neuroendocrine neoplasm, which is most frequently found in the lungs. Extrapulmonary location of SCC is rare and may involve 2.5-5% of SCCs. We present a case of a 31-year-old male patient with an extremely uncommon subglottic SCC. The patient was qualified for a radical sequential chemoradiotherapy. After treatment, patient’s condition suggested complete remission. Recurrence was detected one year later, and the disease rapidly progressed, despite a second line chemotherapy. The patient died 29 months after initial diagnosis. This case aims to raise awareness on the aggressive laryngeal SCC and its good response to first line chemotherapy composed of cisplatin and etoposide, followed by radiotherapy.
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spelling pubmed-105608482023-10-10 Small cell carcinoma with neuroendocrine differentiation of subglottic larynx- a case report Becht, Rafał Kiełbowski, Kajetan Żychowska, Justyna Dembowska, Wiktoria Król, Małgorzata Birkenfeld, Bożena Owsiak, Mateusz Lewandowska, Magdalena Kubrak, Jadwiga Amernik, Katarzyna Front Oncol Oncology Small cell cancer (SCC) is a neuroendocrine neoplasm, which is most frequently found in the lungs. Extrapulmonary location of SCC is rare and may involve 2.5-5% of SCCs. We present a case of a 31-year-old male patient with an extremely uncommon subglottic SCC. The patient was qualified for a radical sequential chemoradiotherapy. After treatment, patient’s condition suggested complete remission. Recurrence was detected one year later, and the disease rapidly progressed, despite a second line chemotherapy. The patient died 29 months after initial diagnosis. This case aims to raise awareness on the aggressive laryngeal SCC and its good response to first line chemotherapy composed of cisplatin and etoposide, followed by radiotherapy. Frontiers Media S.A. 2023-09-25 /pmc/articles/PMC10560848/ /pubmed/37817765 http://dx.doi.org/10.3389/fonc.2023.1222418 Text en Copyright © 2023 Becht, Kiełbowski, Żychowska, Dembowska, Król, Birkenfeld, Owsiak, Lewandowska, Kubrak and Amernik https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Becht, Rafał
Kiełbowski, Kajetan
Żychowska, Justyna
Dembowska, Wiktoria
Król, Małgorzata
Birkenfeld, Bożena
Owsiak, Mateusz
Lewandowska, Magdalena
Kubrak, Jadwiga
Amernik, Katarzyna
Small cell carcinoma with neuroendocrine differentiation of subglottic larynx- a case report
title Small cell carcinoma with neuroendocrine differentiation of subglottic larynx- a case report
title_full Small cell carcinoma with neuroendocrine differentiation of subglottic larynx- a case report
title_fullStr Small cell carcinoma with neuroendocrine differentiation of subglottic larynx- a case report
title_full_unstemmed Small cell carcinoma with neuroendocrine differentiation of subglottic larynx- a case report
title_short Small cell carcinoma with neuroendocrine differentiation of subglottic larynx- a case report
title_sort small cell carcinoma with neuroendocrine differentiation of subglottic larynx- a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560848/
https://www.ncbi.nlm.nih.gov/pubmed/37817765
http://dx.doi.org/10.3389/fonc.2023.1222418
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