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Correlation between lenticulostriate arteries and white matter microstructure changes in patients with cerebral small vessel disease
To explore the correlation between the number of lenticulostriate arteries (LSAs) and the white matter features in cerebral small vessel diseases (CSVD) by 3T magnetic resonance imaging (MRI). Seventy-one patients with diagnoses of CSVD were prospectively enrolled to undergo 3T MRI examination, incl...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560852/ https://www.ncbi.nlm.nih.gov/pubmed/37817799 http://dx.doi.org/10.3389/fnins.2023.1202538 |
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author | Zhang, Yukun Chang, Peipei Liu, Na Jiang, Yuhan Chu, Ying Du, Wei Lin, Liangjie Gao, Bingbing Li, Yuan Qu, Mingrui Yang, Chao Miao, YanWei |
author_facet | Zhang, Yukun Chang, Peipei Liu, Na Jiang, Yuhan Chu, Ying Du, Wei Lin, Liangjie Gao, Bingbing Li, Yuan Qu, Mingrui Yang, Chao Miao, YanWei |
author_sort | Zhang, Yukun |
collection | PubMed |
description | To explore the correlation between the number of lenticulostriate arteries (LSAs) and the white matter features in cerebral small vessel diseases (CSVD) by 3T magnetic resonance imaging (MRI). Seventy-one patients with diagnoses of CSVD were prospectively enrolled to undergo 3T MRI examination, including high-resolution vascular wall imaging (VWI) and diffusion tensor imaging (DTI). The LSAs were observed and counted on VWI, and the patients were divided into three groups according to the LSA counts. The presence of white matter hyperintensities (WMHs), lacunes, cerebral microbleeds (CMBs), and enlarged perivascular spaces (EPVS) was assessed in each patient, and a composite CSVD score was calculated. Periventricular and deep white matter hyperintensity (PVWMH, DWMH) volume ratios were obtained based on automatic segmentation. Fractional anisotropy (FA) and mean diffusivity (MD) were processed by using tract-based spatial statistics (TBSS) analysis. These parameters were compared among the three groups. Correlations between the LSA counts and white matter features were also analyzed. There were differences in WMHs (P = 0.001), CMBs (P < 0.001), EPVS (P = 0.017), composite CSVD scores (P < 0.001), PVWMH volume ratios (P = 0.001), DWMH volume ratios (P < 0.001), global FA (P = 0.001), and global MD (P = 0.002) among the three groups. There were correlations between the LSA counts and WMHs (r = −0.45, P < 0.001), CMBs (r = −0.44, P < 0.001), EPVS (r = −0.28, P = 0.020), the composite CSVD score (r = −0.52, P < 0.001), DWMH volume ratio (r = −0.47, P < 0.001), PWMH volume ratio (r = −0.34, P = 0.004), global FA (r = 0.36, P = 0.002), and global MD (r = −0.33, P = 0.005). Diabetes mellitus (OR 3.36, 95% CI 1.06–10.63; P = 0.039) and increased DWMH volume ratios (OR 1.04, 95% CI 1.00–1.08; P = 0.048) were independent risk factors for a decrease in LSA counts. TBSS analysis showed differences among the three groups in global FA and MD after adjusting for age and sex (P < 0.05). The LSA counts was associated with white matter microstructure changes in CSVD and has the potential to represent the extent of subcortical microvascular damage in CSVD patients. |
format | Online Article Text |
id | pubmed-10560852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105608522023-10-10 Correlation between lenticulostriate arteries and white matter microstructure changes in patients with cerebral small vessel disease Zhang, Yukun Chang, Peipei Liu, Na Jiang, Yuhan Chu, Ying Du, Wei Lin, Liangjie Gao, Bingbing Li, Yuan Qu, Mingrui Yang, Chao Miao, YanWei Front Neurosci Neuroscience To explore the correlation between the number of lenticulostriate arteries (LSAs) and the white matter features in cerebral small vessel diseases (CSVD) by 3T magnetic resonance imaging (MRI). Seventy-one patients with diagnoses of CSVD were prospectively enrolled to undergo 3T MRI examination, including high-resolution vascular wall imaging (VWI) and diffusion tensor imaging (DTI). The LSAs were observed and counted on VWI, and the patients were divided into three groups according to the LSA counts. The presence of white matter hyperintensities (WMHs), lacunes, cerebral microbleeds (CMBs), and enlarged perivascular spaces (EPVS) was assessed in each patient, and a composite CSVD score was calculated. Periventricular and deep white matter hyperintensity (PVWMH, DWMH) volume ratios were obtained based on automatic segmentation. Fractional anisotropy (FA) and mean diffusivity (MD) were processed by using tract-based spatial statistics (TBSS) analysis. These parameters were compared among the three groups. Correlations between the LSA counts and white matter features were also analyzed. There were differences in WMHs (P = 0.001), CMBs (P < 0.001), EPVS (P = 0.017), composite CSVD scores (P < 0.001), PVWMH volume ratios (P = 0.001), DWMH volume ratios (P < 0.001), global FA (P = 0.001), and global MD (P = 0.002) among the three groups. There were correlations between the LSA counts and WMHs (r = −0.45, P < 0.001), CMBs (r = −0.44, P < 0.001), EPVS (r = −0.28, P = 0.020), the composite CSVD score (r = −0.52, P < 0.001), DWMH volume ratio (r = −0.47, P < 0.001), PWMH volume ratio (r = −0.34, P = 0.004), global FA (r = 0.36, P = 0.002), and global MD (r = −0.33, P = 0.005). Diabetes mellitus (OR 3.36, 95% CI 1.06–10.63; P = 0.039) and increased DWMH volume ratios (OR 1.04, 95% CI 1.00–1.08; P = 0.048) were independent risk factors for a decrease in LSA counts. TBSS analysis showed differences among the three groups in global FA and MD after adjusting for age and sex (P < 0.05). The LSA counts was associated with white matter microstructure changes in CSVD and has the potential to represent the extent of subcortical microvascular damage in CSVD patients. Frontiers Media S.A. 2023-09-25 /pmc/articles/PMC10560852/ /pubmed/37817799 http://dx.doi.org/10.3389/fnins.2023.1202538 Text en Copyright © 2023 Zhang, Chang, Liu, Jiang, Chu, Du, Lin, Gao, Li, Qu, Yang and Miao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhang, Yukun Chang, Peipei Liu, Na Jiang, Yuhan Chu, Ying Du, Wei Lin, Liangjie Gao, Bingbing Li, Yuan Qu, Mingrui Yang, Chao Miao, YanWei Correlation between lenticulostriate arteries and white matter microstructure changes in patients with cerebral small vessel disease |
title | Correlation between lenticulostriate arteries and white matter microstructure changes in patients with cerebral small vessel disease |
title_full | Correlation between lenticulostriate arteries and white matter microstructure changes in patients with cerebral small vessel disease |
title_fullStr | Correlation between lenticulostriate arteries and white matter microstructure changes in patients with cerebral small vessel disease |
title_full_unstemmed | Correlation between lenticulostriate arteries and white matter microstructure changes in patients with cerebral small vessel disease |
title_short | Correlation between lenticulostriate arteries and white matter microstructure changes in patients with cerebral small vessel disease |
title_sort | correlation between lenticulostriate arteries and white matter microstructure changes in patients with cerebral small vessel disease |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560852/ https://www.ncbi.nlm.nih.gov/pubmed/37817799 http://dx.doi.org/10.3389/fnins.2023.1202538 |
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