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Pre-clinical lung squamous cell carcinoma mouse models to identify novel biomarkers and therapeutic interventions
Primary lung carcinoma or lung cancer (LC) is classified into small-cell or non-small-cell (NSCLC) lung carcinoma. Lung squamous cell carcinoma (LSCC) is the second most common subtype of NSCLC responsible for 30% of all LCs, and its survival remains low with only 24% of patients living for five yea...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560855/ https://www.ncbi.nlm.nih.gov/pubmed/37817767 http://dx.doi.org/10.3389/fonc.2023.1260411 |
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author | Sahu, Priyanka Donovan, Chantal Paudel, Keshav Raj Pickles, Sophie Chimankar, Vrushali Kim, Richard Y. Horvart, Jay C. Dua, Kamal Ieni, Antonio Nucera, Francesco Bielefeldt-Ohmann, Helle Mazilli, Sarah Caramori, Gaetano Lyons, J. Guy Hansbro, Philip M. |
author_facet | Sahu, Priyanka Donovan, Chantal Paudel, Keshav Raj Pickles, Sophie Chimankar, Vrushali Kim, Richard Y. Horvart, Jay C. Dua, Kamal Ieni, Antonio Nucera, Francesco Bielefeldt-Ohmann, Helle Mazilli, Sarah Caramori, Gaetano Lyons, J. Guy Hansbro, Philip M. |
author_sort | Sahu, Priyanka |
collection | PubMed |
description | Primary lung carcinoma or lung cancer (LC) is classified into small-cell or non-small-cell (NSCLC) lung carcinoma. Lung squamous cell carcinoma (LSCC) is the second most common subtype of NSCLC responsible for 30% of all LCs, and its survival remains low with only 24% of patients living for five years or longer post-diagnosis primarily due to the advanced stage of tumors at the time of diagnosis. The pathogenesis of LSCC is still poorly understood and has hampered the development of effective diagnostics and therapies. This review highlights the known risk factors, genetic and epigenetic alterations, miRNA biomarkers linked to the development and diagnosis of LSCC and the lack of therapeutic strategies to target specifically LSCC. We will also discuss existing animal models of LSCC including carcinogen induced, transgenic and xenograft mouse models, and their advantages and limitations along with the chemopreventive studies and molecular studies conducted using them. The importance of developing new and improved mouse models will also be discussed that will provide further insights into the initiation and progression of LSCC, and enable the identification of new biomarkers and therapeutic targets. |
format | Online Article Text |
id | pubmed-10560855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105608552023-10-10 Pre-clinical lung squamous cell carcinoma mouse models to identify novel biomarkers and therapeutic interventions Sahu, Priyanka Donovan, Chantal Paudel, Keshav Raj Pickles, Sophie Chimankar, Vrushali Kim, Richard Y. Horvart, Jay C. Dua, Kamal Ieni, Antonio Nucera, Francesco Bielefeldt-Ohmann, Helle Mazilli, Sarah Caramori, Gaetano Lyons, J. Guy Hansbro, Philip M. Front Oncol Oncology Primary lung carcinoma or lung cancer (LC) is classified into small-cell or non-small-cell (NSCLC) lung carcinoma. Lung squamous cell carcinoma (LSCC) is the second most common subtype of NSCLC responsible for 30% of all LCs, and its survival remains low with only 24% of patients living for five years or longer post-diagnosis primarily due to the advanced stage of tumors at the time of diagnosis. The pathogenesis of LSCC is still poorly understood and has hampered the development of effective diagnostics and therapies. This review highlights the known risk factors, genetic and epigenetic alterations, miRNA biomarkers linked to the development and diagnosis of LSCC and the lack of therapeutic strategies to target specifically LSCC. We will also discuss existing animal models of LSCC including carcinogen induced, transgenic and xenograft mouse models, and their advantages and limitations along with the chemopreventive studies and molecular studies conducted using them. The importance of developing new and improved mouse models will also be discussed that will provide further insights into the initiation and progression of LSCC, and enable the identification of new biomarkers and therapeutic targets. Frontiers Media S.A. 2023-09-25 /pmc/articles/PMC10560855/ /pubmed/37817767 http://dx.doi.org/10.3389/fonc.2023.1260411 Text en Copyright © 2023 Sahu, Donovan, Paudel, Pickles, Chimankar, Kim, Horvart, Dua, Ieni, Nucera, Bielefeldt-Ohmann, Mazilli, Caramori, Lyons and Hansbro https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Sahu, Priyanka Donovan, Chantal Paudel, Keshav Raj Pickles, Sophie Chimankar, Vrushali Kim, Richard Y. Horvart, Jay C. Dua, Kamal Ieni, Antonio Nucera, Francesco Bielefeldt-Ohmann, Helle Mazilli, Sarah Caramori, Gaetano Lyons, J. Guy Hansbro, Philip M. Pre-clinical lung squamous cell carcinoma mouse models to identify novel biomarkers and therapeutic interventions |
title | Pre-clinical lung squamous cell carcinoma mouse models to identify novel biomarkers and therapeutic interventions |
title_full | Pre-clinical lung squamous cell carcinoma mouse models to identify novel biomarkers and therapeutic interventions |
title_fullStr | Pre-clinical lung squamous cell carcinoma mouse models to identify novel biomarkers and therapeutic interventions |
title_full_unstemmed | Pre-clinical lung squamous cell carcinoma mouse models to identify novel biomarkers and therapeutic interventions |
title_short | Pre-clinical lung squamous cell carcinoma mouse models to identify novel biomarkers and therapeutic interventions |
title_sort | pre-clinical lung squamous cell carcinoma mouse models to identify novel biomarkers and therapeutic interventions |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560855/ https://www.ncbi.nlm.nih.gov/pubmed/37817767 http://dx.doi.org/10.3389/fonc.2023.1260411 |
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