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Modulation of HIV-1 capsid multimerization by sennoside A and sennoside B via interaction with the NTD/CTD interface in capsid hexamer

Small molecules that bind to the pocket targeted by a peptide, termed capsid assembly inhibitor (CAI), have shown antiviral effects with unique mechanisms of action. We report the discovery of two natural compounds, sennoside A (SA) and sennoside B (SB), derived from medicinal plants that bind to th...

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Detalles Bibliográficos
Autores principales:	Zhang, Da-Wei, Xu, Xiao-Shuang, Zhou, Rui, Fu, Zhiguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561090/ https://www.ncbi.nlm.nih.gov/pubmed/37817748 http://dx.doi.org/10.3389/fmicb.2023.1270258

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