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NLR receptors in plant immunity: making sense of the alphabet soup
Plants coordinately use cell‐surface and intracellular immune receptors to perceive pathogens and mount an immune response. Intracellular events of pathogen recognition are largely mediated by immune receptors of the nucleotide binding and leucine rich‐repeat (NLR) classes. Upon pathogen perception,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561179/ https://www.ncbi.nlm.nih.gov/pubmed/37602936 http://dx.doi.org/10.15252/embr.202357495 |
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author | Contreras, Mauricio P Lüdke, Daniel Pai, Hsuan Toghani, AmirAli Kamoun, Sophien |
author_facet | Contreras, Mauricio P Lüdke, Daniel Pai, Hsuan Toghani, AmirAli Kamoun, Sophien |
author_sort | Contreras, Mauricio P |
collection | PubMed |
description | Plants coordinately use cell‐surface and intracellular immune receptors to perceive pathogens and mount an immune response. Intracellular events of pathogen recognition are largely mediated by immune receptors of the nucleotide binding and leucine rich‐repeat (NLR) classes. Upon pathogen perception, NLRs trigger a potent broad‐spectrum immune reaction, usually accompanied by a form of programmed cell death termed the hypersensitive response. Some plant NLRs act as multifunctional singleton receptors which combine pathogen detection and immune signaling. However, NLRs can also function in higher order pairs and networks of functionally specialized interconnected receptors. In this article, we cover the basic aspects of plant NLR biology with an emphasis on NLR networks. We highlight some of the recent advances in NLR structure, function, and activation and discuss emerging topics such as modulator NLRs, pathogen suppression of NLRs, and NLR bioengineering. Multi‐disciplinary approaches are required to disentangle how these NLR immune receptor pairs and networks function and evolve. Answering these questions holds the potential to deepen our understanding of the plant immune system and unlock a new era of disease resistance breeding. |
format | Online Article Text |
id | pubmed-10561179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105611792023-10-10 NLR receptors in plant immunity: making sense of the alphabet soup Contreras, Mauricio P Lüdke, Daniel Pai, Hsuan Toghani, AmirAli Kamoun, Sophien EMBO Rep Reviews Plants coordinately use cell‐surface and intracellular immune receptors to perceive pathogens and mount an immune response. Intracellular events of pathogen recognition are largely mediated by immune receptors of the nucleotide binding and leucine rich‐repeat (NLR) classes. Upon pathogen perception, NLRs trigger a potent broad‐spectrum immune reaction, usually accompanied by a form of programmed cell death termed the hypersensitive response. Some plant NLRs act as multifunctional singleton receptors which combine pathogen detection and immune signaling. However, NLRs can also function in higher order pairs and networks of functionally specialized interconnected receptors. In this article, we cover the basic aspects of plant NLR biology with an emphasis on NLR networks. We highlight some of the recent advances in NLR structure, function, and activation and discuss emerging topics such as modulator NLRs, pathogen suppression of NLRs, and NLR bioengineering. Multi‐disciplinary approaches are required to disentangle how these NLR immune receptor pairs and networks function and evolve. Answering these questions holds the potential to deepen our understanding of the plant immune system and unlock a new era of disease resistance breeding. John Wiley and Sons Inc. 2023-08-21 /pmc/articles/PMC10561179/ /pubmed/37602936 http://dx.doi.org/10.15252/embr.202357495 Text en © 2023 The Authors. Published under the terms of the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Contreras, Mauricio P Lüdke, Daniel Pai, Hsuan Toghani, AmirAli Kamoun, Sophien NLR receptors in plant immunity: making sense of the alphabet soup |
title | NLR receptors in plant immunity: making sense of the alphabet soup |
title_full | NLR receptors in plant immunity: making sense of the alphabet soup |
title_fullStr | NLR receptors in plant immunity: making sense of the alphabet soup |
title_full_unstemmed | NLR receptors in plant immunity: making sense of the alphabet soup |
title_short | NLR receptors in plant immunity: making sense of the alphabet soup |
title_sort | nlr receptors in plant immunity: making sense of the alphabet soup |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561179/ https://www.ncbi.nlm.nih.gov/pubmed/37602936 http://dx.doi.org/10.15252/embr.202357495 |
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