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DNA methylation-based diagnosis confirmation in a pediatric patient with low-grade glioma: a case report

Central nervous system (CNS) tumors in children comprise a highly heterogenous and complex group of diseases. Historically, diagnosis and confirmation of these tumors were routinely based on histological examination. However, recently obtained data demonstrate that such a diagnostic approach is not...

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Autores principales: Morgacheva, Daria, Ryzhova, Marina, Zheludkova, Olga, Belogurova, Margarita, Dinikina, Yulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561295/
https://www.ncbi.nlm.nih.gov/pubmed/37818165
http://dx.doi.org/10.3389/fped.2023.1256876
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author Morgacheva, Daria
Ryzhova, Marina
Zheludkova, Olga
Belogurova, Margarita
Dinikina, Yulia
author_facet Morgacheva, Daria
Ryzhova, Marina
Zheludkova, Olga
Belogurova, Margarita
Dinikina, Yulia
author_sort Morgacheva, Daria
collection PubMed
description Central nervous system (CNS) tumors in children comprise a highly heterogenous and complex group of diseases. Historically, diagnosis and confirmation of these tumors were routinely based on histological examination. However, recently obtained data demonstrate that such a diagnostic approach is not completely accurate and could lead to misdiagnosis. Also, in recent times, the quantity and quality of molecular diagnostic methods have greatly improved, which influences the current classification methods and treatment approach for pediatric CNS tumors. Nowadays, molecular methods, such as DNA methylation profiling, are an integral part of diagnosing brain and spinal tumors in children. In this paper, we present the case of an infant with a posterior fossa tumor who demonstrated a non-specific morphology and whose diagnosis was verified only after DNA methylation.
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spelling pubmed-105612952023-10-10 DNA methylation-based diagnosis confirmation in a pediatric patient with low-grade glioma: a case report Morgacheva, Daria Ryzhova, Marina Zheludkova, Olga Belogurova, Margarita Dinikina, Yulia Front Pediatr Pediatrics Central nervous system (CNS) tumors in children comprise a highly heterogenous and complex group of diseases. Historically, diagnosis and confirmation of these tumors were routinely based on histological examination. However, recently obtained data demonstrate that such a diagnostic approach is not completely accurate and could lead to misdiagnosis. Also, in recent times, the quantity and quality of molecular diagnostic methods have greatly improved, which influences the current classification methods and treatment approach for pediatric CNS tumors. Nowadays, molecular methods, such as DNA methylation profiling, are an integral part of diagnosing brain and spinal tumors in children. In this paper, we present the case of an infant with a posterior fossa tumor who demonstrated a non-specific morphology and whose diagnosis was verified only after DNA methylation. Frontiers Media S.A. 2023-09-25 /pmc/articles/PMC10561295/ /pubmed/37818165 http://dx.doi.org/10.3389/fped.2023.1256876 Text en © 2023 Morgacheva, Ryzhova, Zheludkova, Belogurova and Dinikina. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Morgacheva, Daria
Ryzhova, Marina
Zheludkova, Olga
Belogurova, Margarita
Dinikina, Yulia
DNA methylation-based diagnosis confirmation in a pediatric patient with low-grade glioma: a case report
title DNA methylation-based diagnosis confirmation in a pediatric patient with low-grade glioma: a case report
title_full DNA methylation-based diagnosis confirmation in a pediatric patient with low-grade glioma: a case report
title_fullStr DNA methylation-based diagnosis confirmation in a pediatric patient with low-grade glioma: a case report
title_full_unstemmed DNA methylation-based diagnosis confirmation in a pediatric patient with low-grade glioma: a case report
title_short DNA methylation-based diagnosis confirmation in a pediatric patient with low-grade glioma: a case report
title_sort dna methylation-based diagnosis confirmation in a pediatric patient with low-grade glioma: a case report
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561295/
https://www.ncbi.nlm.nih.gov/pubmed/37818165
http://dx.doi.org/10.3389/fped.2023.1256876
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