Cargando…
Monitoring regulatory T cells as a prognostic marker in lung transplantation
Lung transplantation is the major surgical procedure, which restores normal lung functioning and provides years of life for patients suffering from major lung diseases. Lung transplant recipients are at high risk of primary graft dysfunction, and chronic lung allograft dysfunction (CLAD) in the form...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561299/ https://www.ncbi.nlm.nih.gov/pubmed/37818354 http://dx.doi.org/10.3389/fimmu.2023.1235889 |
_version_ | 1785117892915757056 |
---|---|
author | Khan, Mohammad Afzal Lau, Christine L. Krupnick, Alexander Sasha |
author_facet | Khan, Mohammad Afzal Lau, Christine L. Krupnick, Alexander Sasha |
author_sort | Khan, Mohammad Afzal |
collection | PubMed |
description | Lung transplantation is the major surgical procedure, which restores normal lung functioning and provides years of life for patients suffering from major lung diseases. Lung transplant recipients are at high risk of primary graft dysfunction, and chronic lung allograft dysfunction (CLAD) in the form of bronchiolitis obliterative syndrome (BOS). Regulatory T cell (Treg) suppresses effector cells and clinical studies have demonstrated that Treg levels are altered in transplanted lung during BOS progression as compared to normal lung. Here, we discuss levels of Tregs/FOXP3 gene expression as a crucial prognostic biomarker of lung functions during CLAD progression in clinical lung transplant recipients. The review will also discuss Treg mediated immune tolerance, tissue repair, and therapeutic strategies for achieving in-vivo Treg expansion, which will be a potential therapeutic option to reduce inflammation-mediated graft injuries, taper the toxic side effects of ongoing immunosuppressants, and improve lung transplant survival rates. |
format | Online Article Text |
id | pubmed-10561299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105612992023-10-10 Monitoring regulatory T cells as a prognostic marker in lung transplantation Khan, Mohammad Afzal Lau, Christine L. Krupnick, Alexander Sasha Front Immunol Immunology Lung transplantation is the major surgical procedure, which restores normal lung functioning and provides years of life for patients suffering from major lung diseases. Lung transplant recipients are at high risk of primary graft dysfunction, and chronic lung allograft dysfunction (CLAD) in the form of bronchiolitis obliterative syndrome (BOS). Regulatory T cell (Treg) suppresses effector cells and clinical studies have demonstrated that Treg levels are altered in transplanted lung during BOS progression as compared to normal lung. Here, we discuss levels of Tregs/FOXP3 gene expression as a crucial prognostic biomarker of lung functions during CLAD progression in clinical lung transplant recipients. The review will also discuss Treg mediated immune tolerance, tissue repair, and therapeutic strategies for achieving in-vivo Treg expansion, which will be a potential therapeutic option to reduce inflammation-mediated graft injuries, taper the toxic side effects of ongoing immunosuppressants, and improve lung transplant survival rates. Frontiers Media S.A. 2023-09-25 /pmc/articles/PMC10561299/ /pubmed/37818354 http://dx.doi.org/10.3389/fimmu.2023.1235889 Text en Copyright © 2023 Khan, Lau and Krupnick https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Khan, Mohammad Afzal Lau, Christine L. Krupnick, Alexander Sasha Monitoring regulatory T cells as a prognostic marker in lung transplantation |
title | Monitoring regulatory T cells as a prognostic marker in lung transplantation |
title_full | Monitoring regulatory T cells as a prognostic marker in lung transplantation |
title_fullStr | Monitoring regulatory T cells as a prognostic marker in lung transplantation |
title_full_unstemmed | Monitoring regulatory T cells as a prognostic marker in lung transplantation |
title_short | Monitoring regulatory T cells as a prognostic marker in lung transplantation |
title_sort | monitoring regulatory t cells as a prognostic marker in lung transplantation |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561299/ https://www.ncbi.nlm.nih.gov/pubmed/37818354 http://dx.doi.org/10.3389/fimmu.2023.1235889 |
work_keys_str_mv | AT khanmohammadafzal monitoringregulatorytcellsasaprognosticmarkerinlungtransplantation AT lauchristinel monitoringregulatorytcellsasaprognosticmarkerinlungtransplantation AT krupnickalexandersasha monitoringregulatorytcellsasaprognosticmarkerinlungtransplantation |