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Monitoring regulatory T cells as a prognostic marker in lung transplantation

Lung transplantation is the major surgical procedure, which restores normal lung functioning and provides years of life for patients suffering from major lung diseases. Lung transplant recipients are at high risk of primary graft dysfunction, and chronic lung allograft dysfunction (CLAD) in the form...

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Autores principales: Khan, Mohammad Afzal, Lau, Christine L., Krupnick, Alexander Sasha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561299/
https://www.ncbi.nlm.nih.gov/pubmed/37818354
http://dx.doi.org/10.3389/fimmu.2023.1235889
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author Khan, Mohammad Afzal
Lau, Christine L.
Krupnick, Alexander Sasha
author_facet Khan, Mohammad Afzal
Lau, Christine L.
Krupnick, Alexander Sasha
author_sort Khan, Mohammad Afzal
collection PubMed
description Lung transplantation is the major surgical procedure, which restores normal lung functioning and provides years of life for patients suffering from major lung diseases. Lung transplant recipients are at high risk of primary graft dysfunction, and chronic lung allograft dysfunction (CLAD) in the form of bronchiolitis obliterative syndrome (BOS). Regulatory T cell (Treg) suppresses effector cells and clinical studies have demonstrated that Treg levels are altered in transplanted lung during BOS progression as compared to normal lung. Here, we discuss levels of Tregs/FOXP3 gene expression as a crucial prognostic biomarker of lung functions during CLAD progression in clinical lung transplant recipients. The review will also discuss Treg mediated immune tolerance, tissue repair, and therapeutic strategies for achieving in-vivo Treg expansion, which will be a potential therapeutic option to reduce inflammation-mediated graft injuries, taper the toxic side effects of ongoing immunosuppressants, and improve lung transplant survival rates.
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spelling pubmed-105612992023-10-10 Monitoring regulatory T cells as a prognostic marker in lung transplantation Khan, Mohammad Afzal Lau, Christine L. Krupnick, Alexander Sasha Front Immunol Immunology Lung transplantation is the major surgical procedure, which restores normal lung functioning and provides years of life for patients suffering from major lung diseases. Lung transplant recipients are at high risk of primary graft dysfunction, and chronic lung allograft dysfunction (CLAD) in the form of bronchiolitis obliterative syndrome (BOS). Regulatory T cell (Treg) suppresses effector cells and clinical studies have demonstrated that Treg levels are altered in transplanted lung during BOS progression as compared to normal lung. Here, we discuss levels of Tregs/FOXP3 gene expression as a crucial prognostic biomarker of lung functions during CLAD progression in clinical lung transplant recipients. The review will also discuss Treg mediated immune tolerance, tissue repair, and therapeutic strategies for achieving in-vivo Treg expansion, which will be a potential therapeutic option to reduce inflammation-mediated graft injuries, taper the toxic side effects of ongoing immunosuppressants, and improve lung transplant survival rates. Frontiers Media S.A. 2023-09-25 /pmc/articles/PMC10561299/ /pubmed/37818354 http://dx.doi.org/10.3389/fimmu.2023.1235889 Text en Copyright © 2023 Khan, Lau and Krupnick https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Khan, Mohammad Afzal
Lau, Christine L.
Krupnick, Alexander Sasha
Monitoring regulatory T cells as a prognostic marker in lung transplantation
title Monitoring regulatory T cells as a prognostic marker in lung transplantation
title_full Monitoring regulatory T cells as a prognostic marker in lung transplantation
title_fullStr Monitoring regulatory T cells as a prognostic marker in lung transplantation
title_full_unstemmed Monitoring regulatory T cells as a prognostic marker in lung transplantation
title_short Monitoring regulatory T cells as a prognostic marker in lung transplantation
title_sort monitoring regulatory t cells as a prognostic marker in lung transplantation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561299/
https://www.ncbi.nlm.nih.gov/pubmed/37818354
http://dx.doi.org/10.3389/fimmu.2023.1235889
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