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Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System in Hepatocellular Carcinoma ≤5 cm: Biological Characteristics and Patient Outcomes

INTRODUCTION: The present study aimed to evaluate the influence of biological characteristics of hepatocellular carcinoma (HCC) on the Liver Imaging Reporting and Data System (LI-RADS) v2017 category of contrast-enhanced ultrasound (CEUS) in patients with high risk and compare the outcomes among dif...

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Autores principales: Cai, Wen-Jia, Ying, Minghua, Zheng, Rong-Qin, Liao, Jintang, Luo, Baoming, Tang, Lina, Cheng, Wen, Yang, Hong, Wei, An, Yang, Yilin, Wang, Hui, Luo, Yan-Chun, Liu, Cun, Zhong, Hui, Yang, Qi, Yu, Jie, Liang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561321/
https://www.ncbi.nlm.nih.gov/pubmed/37817756
http://dx.doi.org/10.1159/000527498
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author Cai, Wen-Jia
Ying, Minghua
Zheng, Rong-Qin
Liao, Jintang
Luo, Baoming
Tang, Lina
Cheng, Wen
Yang, Hong
Wei, An
Yang, Yilin
Wang, Hui
Luo, Yan-Chun
Liu, Cun
Zhong, Hui
Yang, Qi
Yu, Jie
Liang, Ping
author_facet Cai, Wen-Jia
Ying, Minghua
Zheng, Rong-Qin
Liao, Jintang
Luo, Baoming
Tang, Lina
Cheng, Wen
Yang, Hong
Wei, An
Yang, Yilin
Wang, Hui
Luo, Yan-Chun
Liu, Cun
Zhong, Hui
Yang, Qi
Yu, Jie
Liang, Ping
author_sort Cai, Wen-Jia
collection PubMed
description INTRODUCTION: The present study aimed to evaluate the influence of biological characteristics of hepatocellular carcinoma (HCC) on the Liver Imaging Reporting and Data System (LI-RADS) v2017 category of contrast-enhanced ultrasound (CEUS) in patients with high risk and compare the outcomes among different categories after radical resection. METHODS: Between June 2017 and December 2020, standardized CEUS data of liver nodules were prospectively collected from multiple centers across China. We conducted a retrospective analysis of the prospectively collected data on HCCs measuring no more than 5 cm, as diagnosed by pathology. LI-RADS categories were assigned after thorough evaluation of CEUS features. Then, CEUS LI-RADS categories and major features were compared in different differentiation, Ki-67, and microvascular invasion (MVI) statuses. Differences in recurrence-free survival (RFS) among different LI-RADS categories were further analyzed. RESULTS: A total of 293 HCC nodules in 293 patients were included. This study revealed significant differences in the CEUS LI-RADS category of HCCs among differentiation (p < 0.001) and levels of Ki-67 (p = 0.01) and that poor differentiation (32.7% in LR-M, 12% in LR-5, and 6.2% in LR-4) (p < 0.001) and high level of Ki-67 (median value 30%) were more frequently classified into the LR-M category, whereas well differentiation (37.5% in LR-4, 15.1% in LR-5, and 11.5% in LR-M) and low levels of Ki-67 (median value 11%) were more frequently classified into the LR-4 category. No significant differences were found between MVI and CEUS LI-RADS categories (p > 0.05). With a median follow-up of 23 months, HCCs assigned to different CEUS LI-RADS classes showed no significant differences in RFS after resection. CONCLUSIONS: Biological characteristics of HCC, including differentiation and level of Ki-67 expression, could influence major features of CEUS and impact the CEUS LI-RADS category. HCCs in different CEUS LI-RADS categories showed no significant differences in RFS after resection.
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spelling pubmed-105613212023-10-10 Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System in Hepatocellular Carcinoma ≤5 cm: Biological Characteristics and Patient Outcomes Cai, Wen-Jia Ying, Minghua Zheng, Rong-Qin Liao, Jintang Luo, Baoming Tang, Lina Cheng, Wen Yang, Hong Wei, An Yang, Yilin Wang, Hui Luo, Yan-Chun Liu, Cun Zhong, Hui Yang, Qi Yu, Jie Liang, Ping Liver Cancer Research Article INTRODUCTION: The present study aimed to evaluate the influence of biological characteristics of hepatocellular carcinoma (HCC) on the Liver Imaging Reporting and Data System (LI-RADS) v2017 category of contrast-enhanced ultrasound (CEUS) in patients with high risk and compare the outcomes among different categories after radical resection. METHODS: Between June 2017 and December 2020, standardized CEUS data of liver nodules were prospectively collected from multiple centers across China. We conducted a retrospective analysis of the prospectively collected data on HCCs measuring no more than 5 cm, as diagnosed by pathology. LI-RADS categories were assigned after thorough evaluation of CEUS features. Then, CEUS LI-RADS categories and major features were compared in different differentiation, Ki-67, and microvascular invasion (MVI) statuses. Differences in recurrence-free survival (RFS) among different LI-RADS categories were further analyzed. RESULTS: A total of 293 HCC nodules in 293 patients were included. This study revealed significant differences in the CEUS LI-RADS category of HCCs among differentiation (p < 0.001) and levels of Ki-67 (p = 0.01) and that poor differentiation (32.7% in LR-M, 12% in LR-5, and 6.2% in LR-4) (p < 0.001) and high level of Ki-67 (median value 30%) were more frequently classified into the LR-M category, whereas well differentiation (37.5% in LR-4, 15.1% in LR-5, and 11.5% in LR-M) and low levels of Ki-67 (median value 11%) were more frequently classified into the LR-4 category. No significant differences were found between MVI and CEUS LI-RADS categories (p > 0.05). With a median follow-up of 23 months, HCCs assigned to different CEUS LI-RADS classes showed no significant differences in RFS after resection. CONCLUSIONS: Biological characteristics of HCC, including differentiation and level of Ki-67 expression, could influence major features of CEUS and impact the CEUS LI-RADS category. HCCs in different CEUS LI-RADS categories showed no significant differences in RFS after resection. S. Karger AG 2023-01-24 /pmc/articles/PMC10561321/ /pubmed/37817756 http://dx.doi.org/10.1159/000527498 Text en Copyright © 2023 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission.
spellingShingle Research Article
Cai, Wen-Jia
Ying, Minghua
Zheng, Rong-Qin
Liao, Jintang
Luo, Baoming
Tang, Lina
Cheng, Wen
Yang, Hong
Wei, An
Yang, Yilin
Wang, Hui
Luo, Yan-Chun
Liu, Cun
Zhong, Hui
Yang, Qi
Yu, Jie
Liang, Ping
Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System in Hepatocellular Carcinoma ≤5 cm: Biological Characteristics and Patient Outcomes
title Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System in Hepatocellular Carcinoma ≤5 cm: Biological Characteristics and Patient Outcomes
title_full Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System in Hepatocellular Carcinoma ≤5 cm: Biological Characteristics and Patient Outcomes
title_fullStr Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System in Hepatocellular Carcinoma ≤5 cm: Biological Characteristics and Patient Outcomes
title_full_unstemmed Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System in Hepatocellular Carcinoma ≤5 cm: Biological Characteristics and Patient Outcomes
title_short Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System in Hepatocellular Carcinoma ≤5 cm: Biological Characteristics and Patient Outcomes
title_sort contrast-enhanced ultrasound liver imaging reporting and data system in hepatocellular carcinoma ≤5 cm: biological characteristics and patient outcomes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561321/
https://www.ncbi.nlm.nih.gov/pubmed/37817756
http://dx.doi.org/10.1159/000527498
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