Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells

To fuel accelerated proliferation, leukaemic cells undergo metabolic deregulation, which can result in specific nutrient dependencies. Here, we perform an amino acid drop‐out screen and apply pre‐clinical models of chronic phase chronic myeloid leukaemia (CML) to identify arginine as a nutrient esse...

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Detalles Bibliográficos
Autores principales: Rattigan, Kevin M, Zarou, Martha M, Brabcova, Zuzana, Prasad, Bodhayan, Zerbst, Désirée, Sarnello, Daniele, Kalkman, Eric R, Ianniciello, Angela, Scott, Mary T, Dunn, Karen, Shokry, Engy, Sumpton, David, Copland, Mhairi, Tardito, Saverio, Vande Voorde, Johan, Mussai, Francis, Cheng, Paul, Helgason, G Vignir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561355/
https://www.ncbi.nlm.nih.gov/pubmed/37489735
http://dx.doi.org/10.15252/embr.202256279

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