Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity

BACKGROUND: Anthracyclines including doxorubicin are essential components of many cancer chemotherapy regimens, but their cardiotoxicity severely limits their use. New strategies for treating anthracycline-induced cardiotoxicity (AIC) are still needed. Anthracycline-induced DNA double-strand break (...

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Detalles Bibliográficos
Autores principales: Chen, Xuechun, Liu, Changtong, Zhao, Hong, Zhong, Yigang, Xu, Yizhou, Wang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561451/
https://www.ncbi.nlm.nih.gov/pubmed/37807075
http://dx.doi.org/10.1186/s13062-023-00412-7

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