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Oxybutynin for Primary Palmer Hyperhidrosis Attenuates Migraine Attacks and Burdens
Migraine is a neurological disorder with recurrent headaches accompanied by burdens in social life. Primary palmar hyperhidrosis is a chronic condition with excessive sweating of the palms that can significantly impair quality of life. Primary hyperhidrosis can cause anxiety, and stress, including a...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cureus
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561519/ https://www.ncbi.nlm.nih.gov/pubmed/37818504 http://dx.doi.org/10.7759/cureus.44826 |
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author | Katsuki, Masahito |
author_facet | Katsuki, Masahito |
author_sort | Katsuki, Masahito |
collection | PubMed |
description | Migraine is a neurological disorder with recurrent headaches accompanied by burdens in social life. Primary palmar hyperhidrosis is a chronic condition with excessive sweating of the palms that can significantly impair quality of life. Primary hyperhidrosis can cause anxiety, and stress, including anxiety, is the most common inducer of migraine headaches. Recently, oxybutynin has been used for primary palmar hyperhidrosis. We herein describe a 26-year-old female migraine patient with primary palmar hyperhidrosis whose migraine attacks and burdens were attenuated after the prescription of an oxybutynin lotion formula. The patient’s monthly headache days (MHD) and monthly acute medication intake days (AMD) at the first visit were 10 and 9. Headache Impact Score 6 (HIT-6) at the initial visit was 63. After the prescription of Japanese herbal kampo medicine Goreisan (TJ-17), Goshuyuto (TJ-31), and 200 mg of valproic acid, MHD, AMD, and HIT-6 decreased gradually. However, these parameters could not improve sufficiently at nine months: MHD 4, AMD 4, and HIT-6 52. We first prescribed a lotion formulation of 20% oxybutynin hydrochloride at nine months. After this, migraine was further attenuated, and stress related to primary palmar hyperhidrosis was reduced; at 12 months, the patient had achieved MHD 2, AMD 2, and HIT-6 48. She will continue receiving primary palmar hyperhidrosis treatment while tapering off migraine prophylaxis. While the exact mechanisms connecting migraine and primary hyperhidrosis remain uncertain, this case raises important questions about the potential interplay between stress, sweating, and migraine triggers. |
format | Online Article Text |
id | pubmed-10561519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-105615192023-10-10 Oxybutynin for Primary Palmer Hyperhidrosis Attenuates Migraine Attacks and Burdens Katsuki, Masahito Cureus Dermatology Migraine is a neurological disorder with recurrent headaches accompanied by burdens in social life. Primary palmar hyperhidrosis is a chronic condition with excessive sweating of the palms that can significantly impair quality of life. Primary hyperhidrosis can cause anxiety, and stress, including anxiety, is the most common inducer of migraine headaches. Recently, oxybutynin has been used for primary palmar hyperhidrosis. We herein describe a 26-year-old female migraine patient with primary palmar hyperhidrosis whose migraine attacks and burdens were attenuated after the prescription of an oxybutynin lotion formula. The patient’s monthly headache days (MHD) and monthly acute medication intake days (AMD) at the first visit were 10 and 9. Headache Impact Score 6 (HIT-6) at the initial visit was 63. After the prescription of Japanese herbal kampo medicine Goreisan (TJ-17), Goshuyuto (TJ-31), and 200 mg of valproic acid, MHD, AMD, and HIT-6 decreased gradually. However, these parameters could not improve sufficiently at nine months: MHD 4, AMD 4, and HIT-6 52. We first prescribed a lotion formulation of 20% oxybutynin hydrochloride at nine months. After this, migraine was further attenuated, and stress related to primary palmar hyperhidrosis was reduced; at 12 months, the patient had achieved MHD 2, AMD 2, and HIT-6 48. She will continue receiving primary palmar hyperhidrosis treatment while tapering off migraine prophylaxis. While the exact mechanisms connecting migraine and primary hyperhidrosis remain uncertain, this case raises important questions about the potential interplay between stress, sweating, and migraine triggers. Cureus 2023-09-07 /pmc/articles/PMC10561519/ /pubmed/37818504 http://dx.doi.org/10.7759/cureus.44826 Text en Copyright © 2023, Katsuki et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Dermatology Katsuki, Masahito Oxybutynin for Primary Palmer Hyperhidrosis Attenuates Migraine Attacks and Burdens |
title | Oxybutynin for Primary Palmer Hyperhidrosis Attenuates Migraine Attacks and Burdens |
title_full | Oxybutynin for Primary Palmer Hyperhidrosis Attenuates Migraine Attacks and Burdens |
title_fullStr | Oxybutynin for Primary Palmer Hyperhidrosis Attenuates Migraine Attacks and Burdens |
title_full_unstemmed | Oxybutynin for Primary Palmer Hyperhidrosis Attenuates Migraine Attacks and Burdens |
title_short | Oxybutynin for Primary Palmer Hyperhidrosis Attenuates Migraine Attacks and Burdens |
title_sort | oxybutynin for primary palmer hyperhidrosis attenuates migraine attacks and burdens |
topic | Dermatology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561519/ https://www.ncbi.nlm.nih.gov/pubmed/37818504 http://dx.doi.org/10.7759/cureus.44826 |
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