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Clinical predictors of wheeze trajectories and associations with allergy in Asian children

BACKGROUND: Childhood wheezing is a highly heterogeneous condition with an incomplete understanding of the characteristics of wheeze trajectories, particularly for persistent wheeze. OBJECTIVE: To characterize predictors and allergic comorbidities of distinct wheeze trajectories in a multiethnic Asi...

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Autores principales: Lau, Hui Xing, Chen, Zhaojin, Van Bever, Hugo, Tham, Elizabeth Huiwen, Chan, Yiong Huak, Yap, Qai Ven, Goh, Anne Eng Neo, Teoh, Oon Hoe, Tan, Kok Hian, Yap, Fabian Kok Peng, Godfrey, Keith M., Eriksson, Johan G., Chong, Yap Seng, Lee, Bee Wah, Shek, Lynette Pei-Chi, Loo, Evelyn Xiu Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Allergy, Asthma, and Immunology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561605/
https://www.ncbi.nlm.nih.gov/pubmed/37419414
http://dx.doi.org/10.1016/j.anai.2023.06.024
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author Lau, Hui Xing
Chen, Zhaojin
Van Bever, Hugo
Tham, Elizabeth Huiwen
Chan, Yiong Huak
Yap, Qai Ven
Goh, Anne Eng Neo
Teoh, Oon Hoe
Tan, Kok Hian
Yap, Fabian Kok Peng
Godfrey, Keith M.
Eriksson, Johan G.
Chong, Yap Seng
Lee, Bee Wah
Shek, Lynette Pei-Chi
Loo, Evelyn Xiu Ling
author_facet Lau, Hui Xing
Chen, Zhaojin
Van Bever, Hugo
Tham, Elizabeth Huiwen
Chan, Yiong Huak
Yap, Qai Ven
Goh, Anne Eng Neo
Teoh, Oon Hoe
Tan, Kok Hian
Yap, Fabian Kok Peng
Godfrey, Keith M.
Eriksson, Johan G.
Chong, Yap Seng
Lee, Bee Wah
Shek, Lynette Pei-Chi
Loo, Evelyn Xiu Ling
author_sort Lau, Hui Xing
collection PubMed
description BACKGROUND: Childhood wheezing is a highly heterogeneous condition with an incomplete understanding of the characteristics of wheeze trajectories, particularly for persistent wheeze. OBJECTIVE: To characterize predictors and allergic comorbidities of distinct wheeze trajectories in a multiethnic Asian cohort. METHODS: A total of 974 mother-child pairs from the prospective Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort were included in this study. Wheeze and allergic comorbidities in the first 8 years of life were assessed using the modified International Study of Asthma and Allergies in Childhood questionnaires and skin prick tests. Group-based trajectory modeling was used to derive wheeze trajectories and regression was used to assess associations with predictive risk factors and allergic comorbidities. RESULTS: There were 4 wheeze trajectories derived, including the following: (1) early-onset with rapid remission from age 3 years (4.5%); (2) late-onset peaking at age 3 years and rapidly remitting from 4 years (8.1%); (3) persistent with a steady increase to age 5 years and high wheeze occurrence until 8 years (4.0%); and (4) no or low wheeze (83.4%). Early-onset wheezing was associated with respiratory infections during infancy and linked to subsequent nonallergic rhinitis throughout childhood. Late-onset and persistent wheeze shared similar origins characterized by parent-reported viral infections in later childhood. However, persistent wheezing was generally more strongly associated with a family history of allergy, parent-reported viral infections in later childhood, and allergic comorbidities as compared with late-onset wheezing. CONCLUSION: The timing of viral infection occurrence may determine the type of wheeze trajectory development in children. Children with a family history of allergy and viral infections in early life may be predisposed to persistent wheeze development and the associated comorbidities of early allergic sensitization and eczema.
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spelling pubmed-105616052023-10-10 Clinical predictors of wheeze trajectories and associations with allergy in Asian children Lau, Hui Xing Chen, Zhaojin Van Bever, Hugo Tham, Elizabeth Huiwen Chan, Yiong Huak Yap, Qai Ven Goh, Anne Eng Neo Teoh, Oon Hoe Tan, Kok Hian Yap, Fabian Kok Peng Godfrey, Keith M. Eriksson, Johan G. Chong, Yap Seng Lee, Bee Wah Shek, Lynette Pei-Chi Loo, Evelyn Xiu Ling Ann Allergy Asthma Immunol Article BACKGROUND: Childhood wheezing is a highly heterogeneous condition with an incomplete understanding of the characteristics of wheeze trajectories, particularly for persistent wheeze. OBJECTIVE: To characterize predictors and allergic comorbidities of distinct wheeze trajectories in a multiethnic Asian cohort. METHODS: A total of 974 mother-child pairs from the prospective Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort were included in this study. Wheeze and allergic comorbidities in the first 8 years of life were assessed using the modified International Study of Asthma and Allergies in Childhood questionnaires and skin prick tests. Group-based trajectory modeling was used to derive wheeze trajectories and regression was used to assess associations with predictive risk factors and allergic comorbidities. RESULTS: There were 4 wheeze trajectories derived, including the following: (1) early-onset with rapid remission from age 3 years (4.5%); (2) late-onset peaking at age 3 years and rapidly remitting from 4 years (8.1%); (3) persistent with a steady increase to age 5 years and high wheeze occurrence until 8 years (4.0%); and (4) no or low wheeze (83.4%). Early-onset wheezing was associated with respiratory infections during infancy and linked to subsequent nonallergic rhinitis throughout childhood. Late-onset and persistent wheeze shared similar origins characterized by parent-reported viral infections in later childhood. However, persistent wheezing was generally more strongly associated with a family history of allergy, parent-reported viral infections in later childhood, and allergic comorbidities as compared with late-onset wheezing. CONCLUSION: The timing of viral infection occurrence may determine the type of wheeze trajectory development in children. Children with a family history of allergy and viral infections in early life may be predisposed to persistent wheeze development and the associated comorbidities of early allergic sensitization and eczema. American College of Allergy, Asthma, and Immunology 2023-10 /pmc/articles/PMC10561605/ /pubmed/37419414 http://dx.doi.org/10.1016/j.anai.2023.06.024 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Lau, Hui Xing
Chen, Zhaojin
Van Bever, Hugo
Tham, Elizabeth Huiwen
Chan, Yiong Huak
Yap, Qai Ven
Goh, Anne Eng Neo
Teoh, Oon Hoe
Tan, Kok Hian
Yap, Fabian Kok Peng
Godfrey, Keith M.
Eriksson, Johan G.
Chong, Yap Seng
Lee, Bee Wah
Shek, Lynette Pei-Chi
Loo, Evelyn Xiu Ling
Clinical predictors of wheeze trajectories and associations with allergy in Asian children
title Clinical predictors of wheeze trajectories and associations with allergy in Asian children
title_full Clinical predictors of wheeze trajectories and associations with allergy in Asian children
title_fullStr Clinical predictors of wheeze trajectories and associations with allergy in Asian children
title_full_unstemmed Clinical predictors of wheeze trajectories and associations with allergy in Asian children
title_short Clinical predictors of wheeze trajectories and associations with allergy in Asian children
title_sort clinical predictors of wheeze trajectories and associations with allergy in asian children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561605/
https://www.ncbi.nlm.nih.gov/pubmed/37419414
http://dx.doi.org/10.1016/j.anai.2023.06.024
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