Epithelioid Angiomyolipoma with Tumor Thrombus into Inferior Vena Cava Presurgically Treated with Combination Therapy of Pembrolizumab and Axitinib: A Case Report

Epithelioid angiomyolipoma (EAML) is a rare variant of AML with malignant potential. It is occasionally difficult to distinguish EAML from renal cell carcinoma (RCC) on imaging. A 72-year-old woman was admitted to our hospital for the treatment of a left renal tumor with relatively high blood flow a...

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Autores principales: Kawasoe, Chihiro, Miyamoto, Yoshi, Ito, Kaoru, Murashima, Takaya, Nagai, Takahiro, Takamori, Hiroki, Kiwaki, Takumi, Kamimura, Toshio, Mukai, Shoichiro, Kamoto, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561617/
https://www.ncbi.nlm.nih.gov/pubmed/37818232
http://dx.doi.org/10.2147/RRU.S425887
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author Kawasoe, Chihiro
Miyamoto, Yoshi
Ito, Kaoru
Murashima, Takaya
Nagai, Takahiro
Takamori, Hiroki
Kiwaki, Takumi
Kamimura, Toshio
Mukai, Shoichiro
Kamoto, Toshiyuki
author_facet Kawasoe, Chihiro
Miyamoto, Yoshi
Ito, Kaoru
Murashima, Takaya
Nagai, Takahiro
Takamori, Hiroki
Kiwaki, Takumi
Kamimura, Toshio
Mukai, Shoichiro
Kamoto, Toshiyuki
author_sort Kawasoe, Chihiro
collection PubMed
description Epithelioid angiomyolipoma (EAML) is a rare variant of AML with malignant potential. It is occasionally difficult to distinguish EAML from renal cell carcinoma (RCC) on imaging. A 72-year-old woman was admitted to our hospital for the treatment of a left renal tumor with relatively high blood flow and a tumor thrombus extending to the inferior vena cava, suggesting RCC. The patient underwent presurgical combination therapy with axitinib and pembrolizumab. This treatment significantly shortened the thrombus, and radical nephrectomy was performed. The pathological findings were compatible with EAML, and the treatment effects were observed. We report a case treated pre-surgically with a combined therapy of pembrolizumab and axitinib, with a favorable response as a treatment option for EAML.
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spelling pubmed-105616172023-10-10 Epithelioid Angiomyolipoma with Tumor Thrombus into Inferior Vena Cava Presurgically Treated with Combination Therapy of Pembrolizumab and Axitinib: A Case Report Kawasoe, Chihiro Miyamoto, Yoshi Ito, Kaoru Murashima, Takaya Nagai, Takahiro Takamori, Hiroki Kiwaki, Takumi Kamimura, Toshio Mukai, Shoichiro Kamoto, Toshiyuki Res Rep Urol Case Report Epithelioid angiomyolipoma (EAML) is a rare variant of AML with malignant potential. It is occasionally difficult to distinguish EAML from renal cell carcinoma (RCC) on imaging. A 72-year-old woman was admitted to our hospital for the treatment of a left renal tumor with relatively high blood flow and a tumor thrombus extending to the inferior vena cava, suggesting RCC. The patient underwent presurgical combination therapy with axitinib and pembrolizumab. This treatment significantly shortened the thrombus, and radical nephrectomy was performed. The pathological findings were compatible with EAML, and the treatment effects were observed. We report a case treated pre-surgically with a combined therapy of pembrolizumab and axitinib, with a favorable response as a treatment option for EAML. Dove 2023-10-05 /pmc/articles/PMC10561617/ /pubmed/37818232 http://dx.doi.org/10.2147/RRU.S425887 Text en © 2023 Kawasoe et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Kawasoe, Chihiro
Miyamoto, Yoshi
Ito, Kaoru
Murashima, Takaya
Nagai, Takahiro
Takamori, Hiroki
Kiwaki, Takumi
Kamimura, Toshio
Mukai, Shoichiro
Kamoto, Toshiyuki
Epithelioid Angiomyolipoma with Tumor Thrombus into Inferior Vena Cava Presurgically Treated with Combination Therapy of Pembrolizumab and Axitinib: A Case Report
title Epithelioid Angiomyolipoma with Tumor Thrombus into Inferior Vena Cava Presurgically Treated with Combination Therapy of Pembrolizumab and Axitinib: A Case Report
title_full Epithelioid Angiomyolipoma with Tumor Thrombus into Inferior Vena Cava Presurgically Treated with Combination Therapy of Pembrolizumab and Axitinib: A Case Report
title_fullStr Epithelioid Angiomyolipoma with Tumor Thrombus into Inferior Vena Cava Presurgically Treated with Combination Therapy of Pembrolizumab and Axitinib: A Case Report
title_full_unstemmed Epithelioid Angiomyolipoma with Tumor Thrombus into Inferior Vena Cava Presurgically Treated with Combination Therapy of Pembrolizumab and Axitinib: A Case Report
title_short Epithelioid Angiomyolipoma with Tumor Thrombus into Inferior Vena Cava Presurgically Treated with Combination Therapy of Pembrolizumab and Axitinib: A Case Report
title_sort epithelioid angiomyolipoma with tumor thrombus into inferior vena cava presurgically treated with combination therapy of pembrolizumab and axitinib: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561617/
https://www.ncbi.nlm.nih.gov/pubmed/37818232
http://dx.doi.org/10.2147/RRU.S425887
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