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ACOT1 deficiency attenuates high-fat diet–induced fat mass gain by increasing energy expenditure

Acyl-CoA thioesterase 1 (ACOT1) catalyzes the hydrolysis of long-chain acyl-CoAs to free fatty acids and CoA and is typically upregulated in obesity. Whether targeting ACOT1 in the setting of high-fat diet–induced (HFD-induced) obesity would be metabolically beneficial is not known. Here we report t...

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Detalles Bibliográficos
Autores principales:	Heden, Timothy D., Franklin, Mallory P., Dailey, Christina, Mashek, Mara T., Chen, Chen, Mashek, Douglas G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561717/ https://www.ncbi.nlm.nih.gov/pubmed/37561578 http://dx.doi.org/10.1172/jci.insight.160987

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