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SETD1A drives stemness by reprogramming the epigenetic landscape in hepatocellular carcinoma stem cells

Cancer stem cells (CSCs) are responsible for tumor progression and recurrence. However, the mechanisms regulating hepatocellular carcinoma (HCC) stemness remain unclear. Applying a genome-scale CRISPR knockout screen, we identified that the H3K4 methyltransferase SETD1A and other members of Trithora...

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Detalles Bibliográficos
Autores principales:	Chen, Jianxu, Xu, Zhijie, Huang, Hongbin, Tang, Yao, Shan, Hong, Xiao, Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561725/ https://www.ncbi.nlm.nih.gov/pubmed/37581938 http://dx.doi.org/10.1172/jci.insight.168375

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