Modulating the polyamine/hypusine axis controls generation of CD8(+) tissue-resident memory T cells

Glutaminolysis is a hallmark of the activation and metabolic reprogramming of T cells. Isotopic tracer analyses of antigen-activated effector CD8(+) T cells revealed that glutamine is the principal carbon source for the biosynthesis of polyamines putrescine, spermidine, and spermine. These metabolit...

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Detalles Bibliográficos
Autores principales: Elmarsafawi, Aya G., Hesterberg, Rebecca S., Fernandez, Mario R., Yang, Chunying, Darville, Lancia N.F., Liu, Min, Koomen, John M., Phanstiel, Otto, Atkins, Reginald, Mullinax, John E., Pilon-Thomas, Shari A., Locke, Frederick L., Epling-Burnette, Pearlie K., Cleveland, John L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561731/
https://www.ncbi.nlm.nih.gov/pubmed/37581943
http://dx.doi.org/10.1172/jci.insight.169308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561731/
https://www.ncbi.nlm.nih.gov/pubmed/37581943
http://dx.doi.org/10.1172/jci.insight.169308

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