Synergistic effect of antagonists to KRas4B/PDE6 molecular complex in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis among all human cancers as it is highly resistant to chemotherapy. K-Ras mutations usually trigger the development and progression of PDAC. We hypothesized that compounds stabilizing the KRas4B/PDE6δ complex could serve as PDAC treatmen...

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Detalles Bibliográficos
Autores principales: Briseño-Díaz, Paola, Schnoor, Michael, Bello-Ramirez, Martiniano, Correa-Basurto, Jose, Rojo-Domínguez, Arturo, Arregui, Leticia, Vega, Libia, Núñez-González, Enrique, Palau-Hernández, Luis Andres, Parra-Torres, Carlos Guadalupe, García Córdova, Óscar Manuel, Zepeda-Castilla, Ernesto, Torices-Escalante, Eduardo, Domínguez-Camacho, Leticia, Xoconostle-Cazares, Beatriz, Meraz-Ríos, Marco Antonio, Delfín-Azuara, Sandra, Carrión-Estrada, Dayan Andrea, Villegas-Sepúlveda, Nicolas, Hernández-Rivas, Rosaura, Thompson-Bonilla, Maria del Rocio, Vargas, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10561825/
https://www.ncbi.nlm.nih.gov/pubmed/37813486
http://dx.doi.org/10.26508/lsa.202302019

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