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Multifunctional magnetic nanoparticles elicit anti-tumor immunity in a mouse melanoma model
Immunotherapy has emerged as a promising strategy to eradicate cancer cells. Particularly, the development of cancer vaccines to induce a potent and sustained antigen-specific T cell response has become a center of attention. Herein, we describe a novel immunotherapy based on magnetic nanoparticles...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562177/ https://www.ncbi.nlm.nih.gov/pubmed/37822453 http://dx.doi.org/10.1016/j.mtbio.2023.100817 |
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author | Lafuente-Gómez, Nuria de Lázaro, Irene Dhanjani, Mónica García-Soriano, David Sobral, Miguel C. Salas, Gorka Mooney, David J. Somoza, Álvaro |
author_facet | Lafuente-Gómez, Nuria de Lázaro, Irene Dhanjani, Mónica García-Soriano, David Sobral, Miguel C. Salas, Gorka Mooney, David J. Somoza, Álvaro |
author_sort | Lafuente-Gómez, Nuria |
collection | PubMed |
description | Immunotherapy has emerged as a promising strategy to eradicate cancer cells. Particularly, the development of cancer vaccines to induce a potent and sustained antigen-specific T cell response has become a center of attention. Herein, we describe a novel immunotherapy based on magnetic nanoparticles (MNP) covalently modified with the OVA(254-267) antigen and a CpG oligonucleotide via disulfide bonds. The MNP-CpG-COVA significantly enhances dendritic cell activation and CD8(+) T cell antitumoral response against B16-OVA melanoma cells in vitro. Notably, the immune response induced by the covalently modified MNP is more potent and sustained over time than that triggered by the free components, highlighting the advantage of nanoformulations in immunotherapies. What is more, the nanoparticles are stable in the blood after in vivo administration and induce potent levels of systemic tumor-specific effector CD8 + T cells. Overall, our findings highlight the potential of covalently functionalized MNP to induce robust immune responses against mouse melanoma. |
format | Online Article Text |
id | pubmed-10562177 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-105621772023-10-11 Multifunctional magnetic nanoparticles elicit anti-tumor immunity in a mouse melanoma model Lafuente-Gómez, Nuria de Lázaro, Irene Dhanjani, Mónica García-Soriano, David Sobral, Miguel C. Salas, Gorka Mooney, David J. Somoza, Álvaro Mater Today Bio Full Length Article Immunotherapy has emerged as a promising strategy to eradicate cancer cells. Particularly, the development of cancer vaccines to induce a potent and sustained antigen-specific T cell response has become a center of attention. Herein, we describe a novel immunotherapy based on magnetic nanoparticles (MNP) covalently modified with the OVA(254-267) antigen and a CpG oligonucleotide via disulfide bonds. The MNP-CpG-COVA significantly enhances dendritic cell activation and CD8(+) T cell antitumoral response against B16-OVA melanoma cells in vitro. Notably, the immune response induced by the covalently modified MNP is more potent and sustained over time than that triggered by the free components, highlighting the advantage of nanoformulations in immunotherapies. What is more, the nanoparticles are stable in the blood after in vivo administration and induce potent levels of systemic tumor-specific effector CD8 + T cells. Overall, our findings highlight the potential of covalently functionalized MNP to induce robust immune responses against mouse melanoma. Elsevier 2023-09-24 /pmc/articles/PMC10562177/ /pubmed/37822453 http://dx.doi.org/10.1016/j.mtbio.2023.100817 Text en © 2023 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Full Length Article Lafuente-Gómez, Nuria de Lázaro, Irene Dhanjani, Mónica García-Soriano, David Sobral, Miguel C. Salas, Gorka Mooney, David J. Somoza, Álvaro Multifunctional magnetic nanoparticles elicit anti-tumor immunity in a mouse melanoma model |
title | Multifunctional magnetic nanoparticles elicit anti-tumor immunity in a mouse melanoma model |
title_full | Multifunctional magnetic nanoparticles elicit anti-tumor immunity in a mouse melanoma model |
title_fullStr | Multifunctional magnetic nanoparticles elicit anti-tumor immunity in a mouse melanoma model |
title_full_unstemmed | Multifunctional magnetic nanoparticles elicit anti-tumor immunity in a mouse melanoma model |
title_short | Multifunctional magnetic nanoparticles elicit anti-tumor immunity in a mouse melanoma model |
title_sort | multifunctional magnetic nanoparticles elicit anti-tumor immunity in a mouse melanoma model |
topic | Full Length Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562177/ https://www.ncbi.nlm.nih.gov/pubmed/37822453 http://dx.doi.org/10.1016/j.mtbio.2023.100817 |
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